Name: Mometasone CAS 105102-22-5: Potent Anti-Inflammatory Solution
Availability: InStock
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Mometasone CAS NO.105102-22-5

Mometasone is a high-potency synthetic steroidal glucocorticoid intermediate, supplied as a premium active pharmaceutical ingredient (API) primarily intended for the synthesis of mometasone furoate and advanced pharmaceutical research. This chlorinated corticosteroid is highly valued by drug manufacturers and R&D laboratories for its exceptional anti-inflammatory, antipruritic, and vasoconstrictive properties, serving as the core structure for developing topical, nasal, and inhaled formulations. It is specifically targeted at pharmaceutical companies, contract manufacturing organizations (CMOs), and research institutions requiring a reliable, high-purity building block to produce next-generation therapies for allergic and inflammatory conditions with enhanced local activity.

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TECHNICAL SPECIFICATIONS

Item	Specification
Product Name	Mometasone
CAS NO.	105102-22-5
Appearance	White to off-white crystalline powder
Molecular Formula	C22H28Cl2O4
Molecular Weight	427.36 g/mol
Purity (RP-HPLC)	≥98.0%
Solubility	Soluble in DMSO, Chloroform; slightly soluble in Ethyl Acetate; insoluble in water
Endotoxin	< 10 EU/mg
Biological Activity	Potent synthetic glucocorticoid receptor agonist with strong anti-inflammatory, immunosuppressive, and antiproliferative activities; used in dermatology and respiratory medicine.
Storage Conditions	Store at -20°C, protected from light and moisture. Keep container tightly sealed.
Stock Location	Stock in USA
MOQ	1g

1.MECHANISM OF ACTION

Mometasone exerts its potent effects by easily diffusing across cell membranes and binding with high affinity to specific cytoplasmic glucocorticoid receptors, forming a complex that translocates into the nucleus to modulate gene expression. This interaction induces the synthesis of anti-inflammatory proteins, such as lipocortins, which inhibit phospholipase A2 and subsequently block the release of arachidonic acid, thereby reducing the biosynthesis of potent inflammatory mediators like prostaglandins and leukotrienes. Furthermore, it suppresses the migration of inflammatory cells, decreases capillary membrane permeability to reduce edema, inhibits the release of histamine and kinins, and interferes with the proliferation of fibroblasts and collagen deposition, effectively controlling both acute and chronic inflammatory responses at the molecular level.

2.PRODUCT INDICATIONS

This compound is indicated for use as a key pharmaceutical intermediate in the production of prescription medications designed to treat a wide array of corticosteroid-responsive conditions, including seasonal and perennial allergic rhinitis, asthma maintenance, and various dermatoses. It is essential for formulators developing nasal sprays to alleviate nasal congestion, sneezing, and rhinorrhea, as well as for creating topical creams, ointments, and lotions to manage the inflammatory and pruritic manifestations of plaque psoriasis, atopic dermatitis, and seborrheic dermatitis. Additionally, it supports the development of inhalation powders for prophylactic asthma therapy, catering to healthcare product manufacturers focused on delivering targeted, localized treatment with minimal systemic exposure for both adult and pediatric populations.

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3.CLINICAL EFFICACY OF PRODUCT

In extensive preclinical and clinical research, the derivatives synthesized from mometasone have demonstrated superior efficacy in significantly reducing nasal airway resistance, improving peak nasal inspiratory flow, and providing rapid relief from ocular and nasal symptoms associated with allergies. Clinical trials highlight its effectiveness in achieving clear or almost clear skin in patients with psoriasis and dramatically reducing itch severity scores in those with atopic dermatitis, often outperforming older corticosteroids in potency while maintaining safety. Moreover, its derivatives exhibit one of the lowest systemic bioavailabilities (<1%) among inhaled corticosteroids, ensuring profound local anti-inflammatory action in the lungs and nasal mucosa to improve asthma control and reduce polyp size without the substantial risk of HPA-axis suppression or systemic side effects commonly seen with less selective steroids.

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4.Certificate

GlobalTech Co., Ltd. is committed to providing high-purity biotechnological peptide products, adhering strictly to quality standards and obtaining internationally recognized certifications.

Our production partners all employ GMP-compliant production systems and possess standardized quality control processes covering raw material procurement, synthesis, purification, testing, packaging, and storage. Each batch of product comes with complete documentation, including a Certificate of Analysis (COA), HPLC purity report, mass spectrometry (MS) chromatograms, and third-party testing reports available upon request.

We prioritize:

1.A rigorous quality management system

2.Batch traceability and stability data

3.Professional laboratory testing and validation

4.Compliance with international trade standards

Our commitment to quality, transparency, and regulatory compliance ensures the provision of reliable, stable, and research-grade peptide products to our global partners.

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5.DELIVERY & SHIPPING

We specialize in global logistics for various cosmetic peptides. Your order will be handled with the utmost care, ensuring safe, reliable, and intact delivery.

Professional and Secure Packaging

Each bottle of peptide is protected with a special packaging solution to ensure stability and integrity during transportation.

We can also customize packaging according to customer needs.

Shipping Methods

Main Method: International Air Freight

We primarily use DHL, FedEx, UPS, and TNT because of their global reliability, speed, and advanced tracking systems. Air freight ensures the fastest transit time and minimizes the impact of environmental factors on the product.

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Global Technology Co., Ltd. is a modern and advanced enterprise specializing in the production and export of active pharmaceutical ingredients (APIs), peptides, and plant extracts. The company invests in and collaborates closely with domestic manufacturers holding GMP, DMF, and FDA certifications, as well as laboratories at renowned universities, to meet diverse customer needs ranging from gram-level to ton-level. This enables Dejurui Pharmaceutical to provide customers with more flexible and convenient access to cost-effective, high-quality products and superior services.

We focus on the research and development and supply of high-quality chemical products, strictly adhering to international standards and quality systems. Our products are stable in performance and reliable in purity, widely used in industrial manufacturing, scientific research, and the fine chemical industry. We provide solid support at every stage with a professional and responsible attitude.

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