Name: Orn8 Urotensin II - Premium Human Research Peptide 479065-85-5
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Orn8, Urotensin II, human CAS NO.479065-85-5

Orn⁸, Urotensin II (human) (CAS NO. 479065-85-5) is a synthetic, site-specifically modified analog of human Urotensin II (U-II), a potent vasoactive cyclic neuropeptide. This research-grade analog features the substitution of the native cysteine at position 8 with ornithine (Orn), disrupting the ability to form the characteristic disulfide bridge. This linearized analog is a crucial tool for investigating the role of the cyclic structure in U-II's biological activity, receptor binding, and for developing novel ligands for the urotensin-II receptor (UT receptor).

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TECHNICAL SPECIFICATIONS

Item	Specification
Product Name	Orn8, Urotensin II, human
CAS NO.	479065-85-5
Appearance	White to off-white lyophilized powder
Molecular Formula	C63H85N13O18S2
Molecular Weight	1376.6/mol
Purity (RP-HPLC)	≥98%
Solubility	Soluble in water (up to 5 mg/mL), dilute acetic acid, or DMSO; also soluble in aqueous buffers
Endotoxin	≤1.0 EU/mg
Biological Activity	Potent agonist of the urotensin II receptor (UT receptor).
Storage Conditions	Store desiccated at -20°C to -80°C; avoid repeated freeze-thaw cycles. Stable for 2–3 years under proper storage.
Stock Location	Stock in USA
MOQ	1g

1.MECHANISM OF ACTION

This linear analog acts as a ligand for the G protein-coupled urotensin-II receptor (UT receptor). The substitution of Cys⁸ with Orn⁸ prevents the formation of the intramolecular disulfide bond, forcing the peptide into a linear conformation. This structural change typically results in a significant reduction or complete loss of the potent vasoconstrictor and cardiorenal effects associated with native cyclic U-II. It functions as a weak agonist or antagonist, providing a means to study the structural requirements for UT receptor activation and to probe receptor-ligand interactions.

2.PRODUCT INDICATIONS

This product is indicated for advanced research in cardiovascular pharmacology, peptide chemistry, and receptor biology. Key applications include: studying the importance of the cyclic structure and specific residues for U-II's biological potency and receptor binding affinity; serving as a negative control or antagonist-like ligand in vascular contraction assays; exploring the structure-activity relationship (SAR) of U-II analogs; and as a precursor for the development of novel linear UT receptor modulators for potential therapeutic intervention in cardiovascular diseases.

3.CLINICAL EFFICACY OF PRODUCT

Orn⁸ Urotensin II is a specialized research compound, not a clinical therapeutic. Its efficacy lies in its role as a definitive scientific tool for understanding U-II's structure-function relationship. Studies using this linearized analog have conclusively demonstrated that the cyclic conformation is essential for U-II's extreme potency.

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