Name: Tubuloside A CAS 112516-05-9 | Powerful Natural Compound
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Tubuloside A CAS NO.112516-05-9

ubuloside A is a high-purity phenylethanoid glycoside naturally isolated from the stems of Cistanche tubulosa(Desert Living Cistanche), supplied as a white crystalline powder primarily intended for pharmacological research, natural product standardization, and antioxidant screening. This bioactive compound serves as a critical reference standard for quality control of Cistanche extracts and is a vital tool for scientists investigating oxidative stress, liver protection, and neuroprotective mechanisms. It is specifically catered to pharmaceutical R&D laboratories, nutraceutical manufacturers, and phytochemical researchers requiring a reliable, highly soluble (in methanol, ethanol, and DMSO) reagent to study free radical scavenging activities and cellular defense systems against toxin-induced injuries.

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TECHNICAL SPECIFICATIONS

Item	Specification
Product Name	Tubuloside A
CAS NO.	112516-05-9
Appearance	White to off-white crystalline powder
Molecular Formula	C37H48O21
Molecular Weight	828.76 g/mol
Purity (RP-HPLC)	≥98%
Solubility	Soluble in DMSO, Methanol, Ethanol; slightly soluble in water
Endotoxin	< 10 EU/mg
Biological Activity	Phenylethanoid glycoside with potent antioxidant, anti-inflammatory, and hepatoprotective (inhibits D-GalN-induced hepatocyte death) activities; isolated from Cistanche tubulosa.
Storage Conditions	Store at -20°C, protected from light and moisture. Keep container tightly sealed.
Stock Location	Stock in USA
MOQ	1g

1.MECHANISM OF ACTION

Tubuloside A exerts its primary biological effects by directly binding to and inhibiting the enzymatic activity of Transglutaminase 2 (TGM2), which subsequently blocks the NF-κB signaling pathway and suppresses mitochondrial-mediated apoptotic cascades to reduce inflammation and fibrosis. Additionally, it activates the Nrf2/HO-1 signaling axis to upregulate endogenous antioxidant enzymes—such as superoxide dismutase and glutathione peroxidase—thereby enhancing the cell's capacity to neutralize reactive oxygen species (ROS) and prevent lipid peroxidation. The compound also scavenges free radicals, including DPPH and superoxide anions, while inhibiting the TGF-β1/Smad pathway to restrict the activation of stellate cells and the excessive deposition of extracellular matrix proteins in various tissues.

2.PRODUCT INDICATIONS

Tubuloside A is indicated for non-clinical research applications focused on hepatoprotection, cardiology, and neurobiology, where it is utilized to study preventative strategies against drug-induced liver injury (e.g., diclofenac or D-galactosamine models) and post-myocardial infarction cardiac remodeling. Researchers employ this compound to investigate anti-fibrotic therapies targeting organ stiffness in the heart and liver, as well as to explore neuroprotective agents that may mitigate forgetfulness or oxidative damage in central nervous system models. Furthermore, it is widely used as a primary pharmaceutical reference standard for analytical method development (HPLC/MS) to quantify active constituents in Cistanche-based dietary supplements, traditional herbal medicines, and anti-aging cosmetic formulations intended for both research and commercial validation.

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3.CLINICAL EFFICACY OF PRODUCT

ubuloside A has demonstrated significant efficacy in preclinical evaluations by markedly reducing mortality rates, decreasing infarct size, and improving cardiac function in rat models of myocardial infarction through the potent inhibition of TGM2 and subsequent suppression of collagen deposition. In hepatotoxicity studies, administration of the compound significantly attenuated the elevation of plasma liver enzymes (AST, ALT, ALP) and kidney function markers (BUN, Creatinine) induced by NSAIDs, outperforming standard controls in restoring organ integrity. Moreover, it exhibits robust free radical scavenging potency—with IC50 values against microsomal lipid peroxidation significantly lower than those of alpha-tocopherol and caffeic acid—and effectively inhibits hepatocyte death at micromolar concentrations, establishing its strong therapeutic potential in oxidative stress-related pathology models.

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4.Certificate

GlobalTech Co., Ltd. is committed to providing high-purity biotechnological peptide products, adhering strictly to quality standards and obtaining internationally recognized certifications.

Our production partners all employ GMP-compliant production systems and possess standardized quality control processes covering raw material procurement, synthesis, purification, testing, packaging, and storage. Each batch of product comes with complete documentation, including a Certificate of Analysis (COA), HPLC purity report, mass spectrometry (MS) chromatograms, and third-party testing reports available upon request.

We prioritize:

1.A rigorous quality management system

2.Batch traceability and stability data

3.Professional laboratory testing and validation

4.Compliance with international trade standards

Our commitment to quality, transparency, and regulatory compliance ensures the provision of reliable, stable, and research-grade peptide products to our global partners.

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5.DELIVERY & SHIPPING

We specialize in global logistics for various cosmetic peptides. Your order will be handled with the utmost care, ensuring safe, reliable, and intact delivery.

Professional and Secure Packaging

Each bottle of peptide is protected with a special packaging solution to ensure stability and integrity during transportation.

We can also customize packaging according to customer needs.

Shipping Methods

Main Method: International Air Freight

We primarily use DHL, FedEx, UPS, and TNT because of their global reliability, speed, and advanced tracking systems. Air freight ensures the fastest transit time and minimizes the impact of environmental factors on the product.

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Global Technology Co., Ltd. is a modern and advanced enterprise specializing in the production and export of active pharmaceutical ingredients (APIs), peptides, and plant extracts. The company invests in and collaborates closely with domestic manufacturers holding GMP, DMF, and FDA certifications, as well as laboratories at renowned universities, to meet diverse customer needs ranging from gram-level to ton-level. This enables Dejurui Pharmaceutical to provide customers with more flexible and convenient access to cost-effective, high-quality products and superior services.

We focus on the research and development and supply of high-quality chemical products, strictly adhering to international standards and quality systems. Our products are stable in performance and reliable in purity, widely used in industrial manufacturing, scientific research, and the fine chemical industry. We provide solid support at every stage with a professional and responsible attitude.

Hot Tags: Tubuloside A, Phenylethanoid Glycoside, Cistanche Tubulosa, Antioxidant, Hepatoprotective, Anti-fibrotic, TGM2 Inhibitor, Nrf2 Activator, Natural Product, Phytochemical, Research Standard, Free Radical Scavenger, Neuroprotective, Cardioprotective

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