Xylazine CAS NO.7361-61-7
Xylazine CAS NO.7361-61-7
TECHNICAL SPECIFICATIONS
| Item | Specification |
|---|---|
| Product Name | Xylazine |
| CAS NO. | 7361 – 61 – 7 |
| Appearance | White to off-white lyophilized powder |
| Molecular Formula | C₁₂H₁₆N₂S |
| Molecular Weight | Approximately 220.33 g/mol |
| Purity (RP-HPLC) | ≥ 98.0% |
| Solubility | Soluble in water, alcohol, and some organic solvents such as DMSO |
| Endotoxin | < 1.0 EU/mg |
| Biological Activity | Xylazine is a sedative, analgesic, and muscle relaxant. It acts by stimulating α₂ – adrenergic receptors in the central nervous system. It has effects on reducing anxiety, inducing sedation, and providing pain relief in animals. In veterinary medicine, it is often used in combination with other agents for procedures such as minor surgeries, examinations, and transportation of animals. |
| Storage Conditions | Store at room temperature (15 – 25 °C), away from light, moisture, and strong oxidizing agents. Keep the container tightly closed when not in use. |
| Stock Location | Stock in USA |
| MOQ | 1g |
1.MECHANISM OF ACTION
Xylazine is a selective α₂-adrenergic receptor agonist that acts primarily in the central nervous system. By stimulating presynaptic α₂-receptors, it inhibits norepinephrine release, leading to sedation, muscle relaxation, and analgesia. This mechanism reduces sympathetic outflow, resulting in decreased heart rate, lowered blood pressure, and a state of calm in animals. Unlike opioids, xylazine does not act on opioid receptors, which makes it useful in veterinary medicine for procedural sedation and pain control. Its effects are rapid in onset and reversible with α₂-antagonists such as yohimbine or atipamezole.
2.PRODUCT INDICATIONS
Primary Therapeutic Target:
Sedation, analgesia, and muscle relaxation in large animals (e.g., horses, cattle, swine) during minor surgical procedures, diagnostic exams, and transport.
Veterinary Applications:
Adjunctive anesthesia in combination with ketamine or other agents for short-term surgical interventions.
Tranquilization for restraint during veterinary examinations or sample collection.
Research Applications:
Studies on α₂-adrenergic receptor pharmacology and central nervous system depressant effects.
Comparative efficacy research with other sedatives and analgesics in animal models.
3.CLINICAL EFFICACY OF PRODUCT
Sedation & Analgesia:
Clinical veterinary studies show rapid onset of sedation (within 5–10 minutes) and effective analgesia lasting 30–60 minutes, depending on dose and species.
Muscle Relaxation:
Provides sufficient muscle relaxation for minor surgical and diagnostic procedures without complete immobilization.
Reversibility:
Effects can be quickly reversed using α₂-antagonists, allowing for faster recovery and reduced risk during procedures.
Safety Profile:
Generally well-tolerated in target animal species when dosed appropriately.
Common adverse effects include bradycardia, hypotension, and transient salivation.
Contraindicated in animals with severe cardiovascular compromise; requires careful monitoring during administration.
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