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Phenacetin CAS NO. 62-44-2

Phenacetin (CAS: 62-44-2) is a well-known analgesic and antipyretic compound historically used for pain relief and fever reduction. It serves as an important research chemical and pharmaceutical intermediate. Phenacetin is valued for its chemical stability, ease of handling, and role in the synthesis of other medicinal compounds, making it a versatile choice for medicinal chemistry studies.

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TECHNICAL SPECIFICATIONS

Item	Specification
Product Name	Phenacetin
CAS NO.	62-44-2
Appearance	White, odorless, crystalline powder; stable under normal conditions
Molecular Formula	C₁₀H₁₃NO₂
Molecular Weight	179.22 g/mol
Purity (RP-HPLC)	≥99.0%
Solubility	Slightly soluble in water (~1 g/1300 mL at 25°C)
Endotoxin	< 1.0 EU/mg
Biological Activity	Analgesic and antipyretic; inhibits prostaglandin synthesis; no longer approved for human use in most countries due to risk of nephrotoxicity and carcinogenicity
Storage Conditions	Store at room temperature (15–25°C) in a dry, well-ventilated area; protect from moisture and direct sunlight; stable for 36 months under proper storage
Stock Location	Stock in USA
MOQ	1g

1.MECHANISM OF ACTION

Phenacetin is metabolized in the liver to form the active compound paracetamol (acetaminophen). The precise mechanism of action for paracetamol is complex and not fully understood, but it is believed to involve the inhibition of the cyclooxygenase (COX) enzyme pathways, particularly COX-2, in the central nervous system. This inhibition reduces the synthesis of prostaglandins, which are mediators of pain and fever. Unlike NSAIDs, it has weak anti-inflammatory activity in peripheral tissues.

2.PRODUCT INDICATIONS

Research and Development: As a reference compound or chemical intermediate in pharmacological, toxicological, and metabolic studies.

Chemical Synthesis: As a precursor or intermediate in the synthesis of other chemical compounds.

3.CLINICAL EFFICACY OF PRODUCT

Historically, Phenacetin was clinically effective for reducing fever (antipyretic) and relieving mild to moderate pain (analgesic). However, its use was discontinued due to severe safety concerns. Long-term or high-dose use was strongly linked to nephrotoxicity (kidney damage), methemoglobinemia, and an increased risk of certain cancers, leading to its removal from the pharmaceutical market in the 1980s. Its historical significance paved the way for the development of safer alternatives like paracetamol.

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