Big Endothelin-1 Fragment (22-38) (human), identified by CAS NO.124932-61-2, is a high-purity synthetic peptide designed as a substrate analog for the endothelin-converting enzyme (ECE). By mimicking the natural C-terminal region of the precursor, this fragment serves as a critical biochemical tool for investigating the enzymatic cleavage mechanisms that regulate the maturation of Big ET-1 into active Endothelin-1 (ET-1), which is pivotal for controlling vascular tone and tissue remodeling.

Engineered for high-precision research, this peptide is indispensable for scientists specializing in cardiovascular pathophysiology. It provides essential insights into the mechanisms underlying hypertension, pulmonary arterial hypertension, and heart failure. By utilizing this fragment as a reference standard, researchers can effectively validate ECE activity and screen for potential enzyme inhibitors, facilitating the development of novel pharmacological interventions for endothelial dysfunction.