Plecanatide CAS NO.467426-54-6
TECHNICAL SPECIFICATIONS
| Item | Specification |
|---|---|
| Product Name | Plecanatide |
| CAS NO. | 467426-54-6 |
| Appearance | White to off-white lyophilized powder; odorless, hygroscopic. |
| Molecular Formula | C65H104N18O26S4 |
| Molecular Weight | 1681.88 g/mol |
| Purity (RP-HPLC) | ≥98.0% |
| Solubility | Freely soluble in water and 0.1 M acetic acid; slightly soluble in methanol, practically insoluble in acetonitrile and ether. |
| Endotoxin | < 1.0 EU/mg |
| Biological Activity | Acts as a guanylate cyclase-C (GC-C) agonist, increasing intestinal fluid secretion and accelerating gastrointestinal transit. |
| Storage Conditions | Store at-20°C in a tightly sealed container, protected from light, moisture, and heat. |
| Stock Location | Stock in USA |
| MOQ | 1g |
1.MECHANISM OF ACTION
Plecanatide and its active metabolite bind to and activate guanylate cyclase-C (GC-C) receptors on the luminal surface of intestinal epithelial cells. This activation increases intracellular and extracellular cyclic guanosine monophosphate (cGMP), which stimulates fluid secretion into the intestinal lumen and accelerates bowel transit. The action is pH-dependent and primarily localized to the proximal small intestine, mimicking the physiological activity of endogenous uroguanylin to normalize bowel function.
2.PRODUCT INDICATIONS
Chronic Idiopathic Constipation (CIC): For the treatment of adults with CIC.
3.CLINICAL EFFICACY OF PRODUCT
In Phase III clinical trials, Plecanatide demonstrated significant efficacy versus placebo. For CIC, it increased the proportion of durable overall responders (patients achieving ≥3 spontaneous bowel movements per week and an increase of ≥1 from baseline for ≥9 weeks).
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