Fmoc-Glu(OtBu)-Gly-OH CAS NO.866044-63-5

Fmoc-Glu(OtBu)-Gly-OH is a standard dipeptide building block for SPPS. Its key feature is the OtBu-protected glutamic acid side chain, which provides a latent site for versatile post-synthetic conjugation (e.g., with dyes, PEG, drugs) after deprotection. It is a fundamental tool for peptide engineering, widely used in drug discovery, bioconjugation, and biomaterials development.

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TECHNICAL SPECIFICATIONS

Item	Specification
Product Name	Fmoc-Glu(OtBu)-Gly-OH
CAS NO.	866044-63-5
Appearance	White to off-white crystalline powder
Molecular Formula	C₂₃H₂₈N₂O₇
Molecular Weight	444.48 g/mol
Purity (RP-HPLC)	≥ 95%
Solubility	Soluble in common organic solvents (DMSO, DMF, methanol, dichloromethane); slightly soluble in water
Endotoxin	< 1.0 EU/mg (if for research/cosmetic grade)
Biological Activity	A high-purity protected dipeptide building block for solid-phase peptide synthesis (SPPS), used in the production of custom peptides, pharmaceutical intermediates, and research reagents
Storage Conditions	Store at 2-8°C in a dry, well-ventilated area, protected from light and moisture; avoid prolonged exposure to air
Stock Location	Stock in USA
MOQ	1g

1.MECHANISM OF ACTION

As a protected dipeptide building block, Fmoc-Glu(OtBu)-Gly-OH serves as a key intermediate in peptide synthesis rather than having direct biological activity. Its mechanism in synthesis involves selective deprotection: the Fmoc group is removed under mild basic conditions (typically piperidine in DMF) to expose the amino group for subsequent coupling, while the OtBu group on glutamic acid's side chain remains intact until final global deprotection with strong acid (e.g., TFA).

2.PRODUCT INDICATIONS

Peptide Synthesis Intermediate – Essential building block for constructing peptide sequences containing Glu-Gly motifs in research and pharmaceutical manufacturing.
Pharmaceutical API Development – Used in synthesizing therapeutic peptides requiring glutamic acid and glycine residues.
Bioconjugation Chemistry – Serves as a spacer or linker component in bioconjugate and drug delivery system development.
Structural Biology Studies – Enables incorporation of specific amino acid pairs for protein structure-function research.
Diagnostic Reagent Production – Used in synthesizing peptide-based diagnostic markers and imaging agents.

3.CLINICAL EFFICACY OF PRODUCT

As a chemical synthesis intermediate, Fmoc-Glu(OtBu)-Gly-OH itself does not possess direct clinical efficacy. Its clinical relevance derives from its role in producing therapeutic peptides with demonstrated efficacy. For example, peptides containing Glu-Gly sequences synthesized using this building block have shown therapeutic potential in various applications: as enzyme inhibitors (where glutamic acid provides critical binding interactions), as immunomodulators (where glycine offers structural flexibility), and as components of targeted drug delivery systems.

4.DELIVERY & SHIPPING

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Professional and Secure Packaging
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Shipping Methods
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