Palmitoyl Hexapeptide-12 CAS NO.171263-26-6

Palmitoyl Hexapeptide-12 CAS NO.171263-26-6

Palmitoyl Hexapeptide-12   CAS NO.171263-26-6

Palmitoyl Hexapeptide-12 CAS NO.171263-26-6

Palmitoyl Hexapeptide-12 CAS NO.171263-26-6

Palmitoyl Hexapeptide-12 (CAS NO. 171263-26-6) is a synthetic, lipid-modified hexapeptide engineered for advanced cosmetic applications. It consists of a specific hexapeptide sequence conjugated to a palmitoyl fatty acid chain, which enhances its skin penetration, stability, and affinity for cell membranes. This peptide is designed as a potent cell-communicating signal peptide that mimics the action of natural growth factors. It primarily functions to stimulate the synthesis of key extracellular matrix (ECM) components in the skin, such as collagen and elastin, thereby improving skin firmness, elasticity, density, and reducing the appearance of wrinkles. It is a high-performance active for premium anti-aging and skin-restoring formulations, supplied as a white to off-white powder.

TECHNICAL SPECIFICATIONS


Item
Specification
Product Name
Palmitoyl Hexapeptide-12
CAS NO.
171263-26-6
Appearance
hite to off-white lyophilized powder; free-flowing, no visible clumps
Molecular Formula
C₄₉H₈₉N₁₁O₉
Molecular Weight
984.30 g/mol
Purity (RP-HPLC)
≥ 98.0%
Solubility

Soluble in water (≥50 mg/mL), easily dissolved in dilute acetic acid or phosphate buffer solutions; slightly soluble in ethanol

Endotoxin< 1.0 EU/mg
Biological Activity
Promotes keratinocyte proliferation and collagen synthesis; exhibits potent anti-aging and skin-rejuvenating effects in vitro assays
Storage Conditions
tore at -20°C to -80°C in a sealed, dry container; avoid repeated freeze-thaw cycles. For short-term storage (≤1 month), 2–8°C is acceptable.
Stock Location
Stock in USA
MOQ
1g


1.MECHANISM OF ACTION

  • Stimulation of Extracellular Matrix (ECM) Synthesis: The peptide's sequence is designed to mimic specific signaling domains. It binds to or modulates receptors on the surface of dermal fibroblasts, triggering intracellular signaling cascades. This leads to the upregulated production of collagen (types I, III, IV), elastin, fibronectin, and glycosaminoglycans (GAGs) – the foundational proteins that provide skin with structure, support, and hydration.
  • Reinforcement of the Dermal-Epidermal Junction (DEJ): By promoting the synthesis of structural proteins like collagen IV and laminin, it helps strengthen the critical connection between the dermis and epidermis. This improves overall skin firmness, resilience, and resistance to sagging.
  • Improvement of Skin Microarchitecture: The net increase in dermal matrix components results in a thicker, denser, and more organized dermis. This translates visibly to plumper, tighter, smoother skin with improved texture and a reduction in the depth of fine lines and wrinkles.

2.PRODUCT INDICATIONS

  • As a core active in intensive anti-wrinkle serums, creams, and concentrates for mature or photoaged skin showing signs of fine lines, deep wrinkles, and loss of firmness.
  • In formulations specifically designed to improve skin elasticity, density, and facial contour, such as firming treatments, neck creams, and lifting serums.
  • For skin rejuvenation and repair products aimed at restoring a more youthful skin architecture and combating visible signs of aging.
  • In comprehensive anti-aging regimens that combine this peptide with other synergistic actives like retinoids, antioxidants, and other peptides for enhanced results.


3.CLINICAL EFFICACY OF PRODUCT

  • Significant Improvement in Skin Firmness and Elasticity: Objective biomechanical measurements (e.g., cutometry) confirm enhanced skin firmness and elasticity with regular use.
  • Visible Reduction in Wrinkles and Fine Lines: Subjective grading and imaging analysis (e.g., VISIA®) show a reduction in the depth, volume, and overall appearance of wrinkles.
  • Increased Skin Density and Smoothness: The skin appears plumper, more refined, and better hydrated due to the enhanced dermal matrix and improved barrier function.
  • Overall More Youthful and Revitalized Appearance: Regular use contributes to a brighter, firmer, and healthier-looking complexion, validating its role as a potent, targeted ingredient for comprehensive skin rejuvenation.

4.Certificate

  • GlobalTech Co., Ltd. is committed to providing high-purity biotechnological peptide products, adhering strictly to quality standards and obtaining internationally recognized certifications.

Our production partners all employ GMP-compliant production systems and possess standardized quality control processes covering raw material procurement, synthesis, purification, testing, packaging, and storage. Each batch of product comes with complete documentation, including a Certificate of Analysis (COA), HPLC purity report, mass spectrometry (MS) chromatograms, and third-party testing reports available upon request.


We prioritize:

1.A rigorous quality management system

2.Batch traceability and stability data

3.Professional laboratory testing and validation

4.Compliance with international trade standards


Our commitment to quality, transparency, and regulatory compliance ensures the provision of reliable, stable, and research-grade peptide products to our global partners.

5.DELIVERY & SHIPPING

We specialize in global logistics for various cosmetic peptides. Your order will be handled with the utmost care, ensuring safe, reliable, and intact delivery.

Professional and Secure Packaging

Each bottle of peptide is protected with a special packaging solution to ensure stability and integrity during transportation.

We can also customize packaging according to customer needs.

Shipping Methods 

Main Method: International Air Freight

We primarily use DHL, FedEx, UPS, and TNT because of their global reliability, speed, and advanced tracking systems. Air freight ensures the fastest transit time and minimizes the impact of environmental factors on the product.

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Global Technology Co., Ltd. is a modern and advanced enterprise specializing in the production and export of active pharmaceutical ingredients (APIs), peptides, and plant extracts. The company invests in and collaborates closely with domestic manufacturers holding GMP, DMF, and FDA certifications, as well as laboratories at renowned universities, to meet diverse customer needs ranging from gram-level to ton-level. This enables Dejurui Pharmaceutical to provide customers with more flexible and convenient access to cost-effective, high-quality products and superior services.

We focus on the research and development and supply of high-quality chemical products, strictly adhering to international standards and quality systems. Our products are stable in performance and reliable in purity, widely used in industrial manufacturing, scientific research, and the fine chemical industry. We provide solid support at every stage with a professional and responsible attitude.


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If you have any product requirements, please send an email to:business@huanqiukeji9.com;whatsapp:852 7084 6510

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