english

Melanotan II CAS NO.121062‑08‑6

Melanotan II is a synthetic cyclic heptapeptide analog of α-melanocyte-stimulating hormone (α-MSH), with molecular formula C₅₀H₆₉N₁₅O₉ and CAS 121062-08-6, supplied as a lyophilized powder for research use. It functions as a potent, non-selective agonist of melanocortin receptors (MC1R, MC3R, MC4R, MC5R), primarily studied for its ability to induce skin pigmentation via melanogenesis, modulate appetite and energy balance, and influence sexual arousal and erectile function in preclinical models. The peptide is characterized by enhanced receptor affinity and prolonged activity compared to endogenous α-MSH, making it a key tool for investigating melanocortin signaling pathways in dermatological, metabolic, and neuroendocrine research.

Send Email

Download

TECHNICAL SPECIFICATIONS

Item	Specification
Product Name	Melanotan II
CAS NO.	121062‑08‑6
Appearance	White to off-white lyophilized powder
Molecular Formula	C₅₀H₆₈N₁₄O₁₀
Molecular Weight	1024.2 g/mol
Amino Acid Sequence	Ac-Nle-cyclo[Asp-His-D-Phe-Arg-Trp-Lys]-NH₂
Purity (RP-HPLC)	≥ 98.0%
Solubility	Soluble in water or dilute acetic acid
Endotoxin	< 1.0 EU/mg
Biological Activity	A synthetic melanocortin receptor agonist that stimulates melanogenesis and skin pigmentation.
Storage Conditions	Store at -20°C, protected from light and moisture.
Stock Location	Stock in USA
MOQ	1g

1.MULTIFUNCTIONAL USES

Melanotan II exerts its effects by binding to and activating melanocortin receptors, with high affinity for MC1R (skin melanocytes), MC3R and MC4R (central nervous system), and MC5R. Activation of MC1R stimulates adenylate cyclase, increasing intracellular cAMP and upregulating tyrosinase activity, leading to eumelanin synthesis and skin darkening. Engagement of MC3R and MC4R in hypothalamic and limbic regions modulates appetite, energy expenditure, and sexual behavior via Gs-protein coupling and downstream cAMP/PKA signaling. The peptide’s cyclic structure and modified amino acid sequence confer resistance to enzymatic degradation, resulting in prolonged receptor stimulation and sustained biological effects compared to linear α-MSH analogs.

2.APPLICATION INDUSTRIES

Melanotan II is indicated exclusively for research applications in dermatology, endocrinology, and neuroscience. It is used in in vitroand in vivostudies to investigate melanogenesis, photoprotection, and pigmentation disorders (e.g., vitiligo models), as well as to probe melanocortin receptor roles in appetite regulation, obesity, and metabolic syndromes. The peptide serves as a tool compound in sexual function research, including erectile dysfunction and sexual arousal mechanisms, and in behavioral studies exploring addiction, autism-like phenotypes, and neuroprotection. It is also employed as a reference standard in receptor binding assays, functional screenings, and structure-activity relationship studies for melanocortin-targeted drug discovery.

3.CLINICAL EFFICACY OF PRODUCT

Melanotan II has no established clinical efficacy or regulatory approval for therapeutic use. Early-phase human trials demonstrated its ability to induce penile erections in men with erectile dysfunction and promote skin tanning with reduced UV exposure, but these studies were small and short-term, with significant side effects (nausea, flushing, priapism, mole darkening). No large-scale, controlled trials have confirmed its safety or efficacy for any medical indication, and long-term risks—including potential melanoma promotion—remain uncharacterized. The peptide’s clinical development has been superseded by more selective analogs (e.g., bremelanotide/PT-141 for sexual dysfunction), and Melanotan II remains strictly a research reagent without validated therapeutic benefit.

4.DELIVERY & SHIPPING

We specialize in global logistics for various cosmetic peptides. Your order will be handled with the utmost care, ensuring safe, reliable, and intact delivery.
Professional and Secure Packaging
Each bottle of peptide is protected with a special packaging solution to ensure stability and integrity during transportation.
We can also customize packaging according to customer needs.
Shipping Methods
Main Method: International Air Freight

We primarily use DHL, FedEx, UPS, and TNT because of their global reliability, speed, and advanced tracking systems. Air freight ensures the fastest transit time and minimizes the impact of environmental factors on the product.