Dulaglutide CAS NO.923950-08-7

Dulaglutide CAS NO.923950-08-7

Dulaglutide CAS NO.923950-08-7

Dulaglutide CAS NO.923950-08-7

Dulaglutide CAS NO.923950-08-7

Dulaglutide is a long-acting glucagon-like peptide-1 (GLP-1) receptor agonist designed for once-weekly subcutaneous administration, offering a convenient treatment option for patients with type 2 diabetes. Its unique structure, featuring two GLP-1 analog molecules fused to an IgG4 Fc fragment, provides an extended half-life of approximately 5 days, eliminating the need for daily injections. This product is available in pre-filled, single-use auto-injector pens, making it suitable for patient self-administration at home, and it is intended to be used as an adjunct to diet and exercise to improve glycemic control and reduce cardiovascular risk in eligible adults.



TECHNICAL SPECIFICATIONS


Item
Specification
Product Name
Dulaglutide
CAS NO.
923950-08-7
Appearance
White to off-white lyophilized powder
Molecular Formula
C149H221N37O49
Molecular Weight
3314.62 g/mol
Purity (RP-HPLC)
≥98%
Solubility

Soluble in water and acidic buffers; insoluble in organic solvents

Endotoxin≤10 EU/mg
Biological Activity
Potent GLP-1 receptor agonist; enhances glucose-dependent insulin secretion and suppresses glucagon release
Storage Conditions
Store at 2–8°C; protect from light; do not freeze
Stock Location
Stock in USA
MOQ
1g


1.MECHANISM OF ACTION

Dulaglutide functions as a potent agonist of the GLP-1 receptor, mimicking the action of the endogenous incretin hormone. Upon binding, it stimulates glucose-dependent insulin secretion from pancreatic beta cells while simultaneously suppressing inappropriate glucagon release from alpha cells, thereby lowering fasting and postprandial glucose levels. Additionally, the mechanism includes a delay in gastric emptying, which contributes to reduced post-meal glucose excursions, and a central effect on the brain that promotes satiety and reduces appetite, which supports weight management in patients using the medication.

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2.PRODUCT INDICATIONS

This product is indicated for adults with type 2 diabetes mellitus to improve glycemic control as an adjunct to diet and exercise, and it is also approved to reduce the risk of major adverse cardiovascular events (MACE) such as heart attack, stroke, or cardiovascular death in adults with type 2 diabetes who have established cardiovascular disease or multiple cardiovascular risk factors. It is suitable for a broad patient population, including those with chronic kidney disease, as it does not require dose adjustment for renal impairment, but it is contraindicated in patients with a personal or family history of medullary thyroid carcinoma or Multiple Endocrine Neoplasia syndrome type 2.

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3.CLINICAL EFFICACY OF PRODUCT

Clinical trials, including the AWARD program and the landmark REWIND study, have demonstrated that dulaglutide provides robust and sustained reductions in HbA1c (typically 0.8% to 1.5%) and promotes modest weight loss. The 1.5 mg dose has shown superiority over sitagliptin, exenatide, and insulin glargine in glycemic control. Crucially, the REWIND trial established its cardiovascular benefit, showing a 12% reduction in MACE, which was significant even in a population with a high proportion of patients without prior cardiovascular events, highlighting its role in primary prevention.

4.Certificate

GlobalTech Co., Ltd. is committed to providing high-purity biotechnological peptide products, adhering strictly to quality standards and obtaining internationally recognized certifications.


Our production partners all employ GMP-compliant production systems and possess standardized quality control processes covering raw material procurement, synthesis, purification, testing, packaging, and storage. Each batch of product comes with complete documentation, including a Certificate of Analysis (COA), HPLC purity report, mass spectrometry (MS) chromatograms, and third-party testing reports available upon request.


We prioritize:

1.A rigorous quality management system

2.Batch traceability and stability data

3.Professional laboratory testing and validation

4.Compliance with international trade standards


Our commitment to quality, transparency, and regulatory compliance ensures the provision of reliable, stable, and research-grade peptide products to our global partners.

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5.DELIVERY & SHIPPING

We specialize in global logistics for various cosmetic peptides. Your order will be handled with the utmost care, ensuring safe, reliable, and intact delivery.

Professional and Secure Packaging

Each bottle of peptide is protected with a special packaging solution to ensure stability and integrity during transportation.

We can also customize packaging according to customer needs.

Shipping Methods 

Main Method: International Air Freight

We primarily use DHL, FedEx, UPS, and TNT because of their global reliability, speed, and advanced tracking systems. Air freight ensures the fastest transit time and minimizes the impact of environmental factors on the product.

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Global Technology Co., Ltd. is a modern and advanced enterprise specializing in the production and export of active pharmaceutical ingredients (APIs), peptides, and plant extracts. The company invests in and collaborates closely with domestic manufacturers holding GMP, DMF, and FDA certifications, as well as laboratories at renowned universities, to meet diverse customer needs ranging from gram-level to ton-level. This enables Dejurui Pharmaceutical to provide customers with more flexible and convenient access to cost-effective, high-quality products and superior services.


We focus on the research and development and supply of high-quality chemical products, strictly adhering to international standards and quality systems. Our products are stable in performance and reliable in purity, widely used in industrial manufacturing, scientific research, and the fine chemical industry. We provide solid support at every stage with a professional and responsible attitude.


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If you have any product requirements, please send an email to:info@huanqiukeji9.com;whatsapp:85246842553

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