Sincalide CAS NO.25126-32-3

Sincalide, with CAS number 25126-32-3, molecular formula C₄₉H₆₂N₁₀O₁₂S₂ and molecular weight 1031.21 g/mol, is a synthetic decapeptide analog of cholecystokinin (CCK). It is primarily used in diagnostic medicine to stimulate gallbladder contraction and pancreatic enzyme secretion, aiding in imaging studies such as gallbladder ejection fraction tests and endoscopic retrograde cholangiopancreatography (ERCP). Sincalide mimics endogenous CCK action, enabling clinicians to evaluate biliary and pancreatic function non-invasively.

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TECHNICAL SPECIFICATIONS

Item	Specification
Product Name	Sincalide
CAS NO.	25126 – 32 – 3
Appearance	White to off-white lyophilized powder
Molecular Formula	C49H62N10O16S3
Amino Acid Sequence	Lys – Asn – Leu – Gly – Gln – Cys – Tyr – Gly – Conh₂
Molecular Weight	1143.29 g/mol
Purity (RP-HPLC)	≥ 98.0%
Solubility	It is soluble in water at appropriate concentrations. It may also be soluble in some organic solvents such as dimethyl sulfoxide (DMSO) under certain conditions
Endotoxin	< 1.0 EU/mg
Biological Activity	Sincalide is a cholecystokinin (CCK) analogue. It has potent biological activity in stimulating gallbladder contraction and pancreatic secretion. In in – vitro and in – vivo assays, it shows specific binding to CCK receptors, and its activity is comparable to natural CCK in terms of physiological responses related to the digestive system.
Storage Conditions	Store at – 20°C in a dry and dark environment. Protect from moisture and light to maintain product stability. Avoid repeated freeze – thaw cycles.
Stock Location	Stock in USA
MOQ	1g

1.MECHANISM OF ACTION

Sincalide acts as a cholecystokinin receptor agonist, binding to CCK-A and CCK-B receptors in the gallbladder and pancreas. This stimulates smooth muscle contraction of the gallbladder, leading to bile expulsion, and triggers enzyme secretion from the exocrine pancreas. The peptide’s structure allows rapid absorption and distribution, producing a short-lived but effective physiological response ideal for diagnostic procedures.

2.PRODUCT INDICATIONS

Primary Target: Diagnostic evaluation of gallbladder motility and pancreatic secretory function.

Medical Imaging: Used in nuclear medicine studies to measure gallbladder ejection fraction and assess biliary dyskinesia.

Endoscopic Procedures: Facilitates cannulation and visualization during ERCP by stimulating ductal secretions.

Research Applications: Investigated for gastrointestinal hormone research and drug development targeting CCK receptors.

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3.CLINICAL EFFICACY OF PRODUCT

Gallbladder Contraction: Induces consistent and measurable gallbladder emptying within 15–30 minutes post-administration.

Pancreatic Secretion: Increases enzyme output, aiding in pancreatic functional assessment.

Diagnostic Accuracy: Enhances visualization and diagnostic precision in biliary and pancreatic imaging studies.

Safety Profile: Generally well-tolerated; transient side effects may include nausea, abdominal cramping, or mild diarrhea. Rare hypersensitivity reactions reported.

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4.Certificate

GlobalTech Co., Ltd. is committed to providing high-purity biotechnological peptide products, adhering strictly to quality standards and obtaining internationally recognized certifications.

Our production partners all employ GMP-compliant production systems and possess standardized quality control processes covering raw material procurement, synthesis, purification, testing, packaging, and storage. Each batch of product comes with complete documentation, including a Certificate of Analysis (COA), HPLC purity report, mass spectrometry (MS) chromatograms, and third-party testing reports available upon request.

We prioritize:

1.A rigorous quality management system

2.Batch traceability and stability data

3.Professional laboratory testing and validation

4.Compliance with international trade standards

Our commitment to quality, transparency, and regulatory compliance ensures the provision of reliable, stable, and research-grade peptide products to our global partners.

5.DELIVERY & SHIPPING

We specialize in global logistics for various cosmetic peptides. Your order will be handled with the utmost care, ensuring safe, reliable, and intact delivery.

Professional and Secure Packaging

Each bottle of peptide is protected with a special packaging solution to ensure stability and integrity during transportation.

We can also customize packaging according to customer needs.

Shipping Methods

Main Method: International Air Freight

We primarily use DHL, FedEx, UPS, and TNT because of their global reliability, speed, and advanced tracking systems. Air freight ensures the fastest transit time and minimizes the impact of environmental factors on the product.

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Global Technology Co., Ltd. is a modern and advanced enterprise specializing in the production and export of active pharmaceutical ingredients (APIs), peptides, and plant extracts. The company invests in and collaborates closely with domestic manufacturers holding GMP, DMF, and FDA certifications, as well as laboratories at renowned universities, to meet diverse customer needs ranging from gram-level to ton-level. This enables Dejurui Pharmaceutical to provide customers with more flexible and convenient access to cost-effective, high-quality products and superior services.

We focus on the research and development and supply of high-quality chemical products, strictly adhering to international standards and quality systems. Our products are stable in performance and reliable in purity, widely used in industrial manufacturing, scientific research, and the fine chemical industry. We provide solid support at every stage with a professional and responsible attitude.

Hot Tags: Sincalide #CCK8 #Cholecystokinin #GallbladderContraction #DiagnosticAgent #PancreaticSecretion #GastroenterologyResearch #PeptideResearch

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