Glepaglutide CAS NO.914009-86-2

Glepaglutide, with CAS number 914009-86-2, molecular formula C197H325N53O55 and molecular weight ~5900 Da, is a long-acting glucagon-like peptide-1 (GLP-1) receptor agonist. It is designed to improve glycemic control and support weight management by mimicking the incretin hormone GLP-1. Glepaglutide is under investigation for the treatment of type 2 diabetes mellitus and obesity, offering once-weekly dosing potential due to its extended half-life.

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TECHNICAL SPECIFICATIONS

Item	Specification
Product Name	Glepaglutide
CAS NO.	914009-86-2
Appearance	White to off-white lyophilized powder
Molecular Formula	C197H325N53O55
Molecular Weight	4316.01 g/mol
Purity (RP-HPLC)	≥ 98.0%
Solubility	Soluble in water
Endotoxin	< 1.0 EU/mg
Biological Activity	Binds to GLP-1R with EC₅₀ of 0.5-1 nM, promotes insulin secretion in vitro
Storage Conditions	Store at -20°C or below in a dry, dark environment.
Stock Location	Stock in USA
MOQ	1g

1.MECHANISM OF ACTION

Glepaglutide selectively binds to the GLP-1 receptor on pancreatic beta cells, enhancing glucose-dependent insulin secretion while suppressing glucagon release. It slows gastric emptying and promotes satiety through central appetite regulation. The fatty acid side chain modification allows prolonged receptor activation, resulting in sustained metabolic effects and less frequent administration compared to native GLP-1.

2.PRODUCT INDICATIONS

Primary Target: Type 2 diabetes mellitus management and obesity treatment.

Metabolic Health: Adjunctive therapy to improve glycemic control and reduce body weight.

Research Applications: Investigated in clinical trials for its long-acting GLP-1 receptor agonist profile.

Formulation Use: Suitable for development of once-weekly injectable formulations.

3.CLINICAL EFFICACY OF PRODUCT

Glycemic Control: Significantly reduces HbA1c levels in type 2 diabetes patients (up to 1.5% reduction in clinical studies).

Weight Loss: Promotes substantial body weight reduction (average 5–10% from baseline).

Dosing Convenience: Once-weekly administration improves patient compliance.

Safety Profile: Generally well-tolerated; common adverse events include nausea, vomiting, and diarrhea, which are usually transient.

4.DELIVERY & SHIPPING

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