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ACTH(1-39) CAS NO.12279-41-3

ACTH(1-39) (CAS No. 12279-41-3) is a bioactive peptide fragment of adrenocorticotropic hormone, with the molecular formula C₂₀₇H₃₀₈N₅₆O₅₈S and a molecular weight of 4541.55 g/mol. It is widely used in endocrine research and diagnostic applications for its role in stimulating adrenal function.

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TECHNICAL SPECIFICATIONS

Item	Specification
Product Name	ACTH(1-39) (Adrenocorticotropic Hormone Fragment 1-39)
CAS NO.	12279-41-3
Appearance	White to off-white lyophilized powder
Molecular Formula	C₂₀₇H₃₀₈N₅₆O₅₈S
Molecular Weight	4541.55g/mol
Amino Acid Sequence	Ser-Tyr-Ser-Met-Glu-His-Phe-Arg-Trp-Gly-Lys-Pro-Val-Gly-Lys-Lys-Arg-Arg-Pro-Val-Lys-Val-Tyr-Pro-Asp-Ala-Gly-Glu-Asp-Gln-Ser-Ala-Glu-Ala-Phe-Pro-Leu-Glu-Phe
Purity (RP-HPLC)	≥95.0% (customizable to ≥98.0%)
Solubility	Soluble in water and dilute acetic acid solutions
Endotoxin	< 1.0 EU/mg
Biological Activity	Stimulates adrenal cortex to secrete corticosteroids; used in research on stress response, adrenal function, and endocrine disorders
Storage Conditions	Store at –20°C, protected from light and moisture. For long-term storage, recommend –80°C.
Stock Location	Stock in USA
MOQ	10mg

1.MECHANISM OF ACTION

ACTH(1-39) acts by binding to melanocortin-2 receptors (MC2R) on adrenal cortex cells, activating adenylate cyclase and increasing intracellular cAMP levels. This stimulates the synthesis and secretion of glucocorticoids (such as cortisol) and adrenal androgens, thereby playing a key role in regulating metabolism, stress response, and immune function.

2.PRODUCT INDICATIONS

This peptide is primarily employed in clinical diagnostics for evaluating adrenal insufficiency and related endocrine disorders. It is also utilized in research on stress physiology, hypothalamic-pituitary-adrenal (HPA) axis regulation, and the development of therapeutic interventions for hormonal imbalances.

3.CLINICAL EFFICACY OF PRODUCT

Studies confirm that ACTH(1-39) enables accurate assessment of adrenal reserve and function, aiding in the diagnosis of conditions such as Addison's disease and secondary adrenal insufficiency. Its reliable bioactivity supports standardized diagnostic protocols and contributes to research on hormone-dependent therapeutic strategies

4.DELIVERY & SHIPPING

We specialize in global logistics for various cosmetic peptides. Your order will be handled with the utmost care, ensuring safe, reliable, and intact delivery.

Professional and Secure Packaging

Each bottle of peptide is protected with a special packaging solution to ensure stability and integrity during transportation.
We can also customize packaging according to customer needs.

Shipping Methods

Main Method: International Air Freight

We primarily use DHL, FedEx, UPS, and TNT because of their global reliability, speed, and advanced tracking systems. Air freight ensures the fastest transit time and minimizes the impact of environmental factors on the product.