Sinapultide CAS NO.138531-07-4
Sinapultide CAS NO.138531-07-4
TECHNICAL SPECIFICATIONS
| Item | Specification |
|---|---|
| Product Name | Sinapultide |
| CAS NO. | 138531-07-4 |
| Appearance | White to off-white lyophilized powder |
| Molecular Formula | C126H238N26022 |
| Molecular Weight | 2469.41 g/mol |
| Purity (RP-HPLC) | ≥ 98.0% |
| Solubility | Soluble in water, dilute saline, and aqueous buffers; sparingly soluble in organic solvents |
| Endotoxin | < 1.0 EU/mg |
| Biological Activity | ≥90% relative potency (measured by surfactant activity and lipid bilayer interaction assays) |
| Storage Conditions | Store at -20°C to -80°C in a dry, dark environment; avoid repeated freeze-thaw cycles. |
| Stock Location | Stock in USA |
| MOQ | 1g |
1.MECHANISM OF ACTION
Sinapultide mimics the action of endogenous surfactant protein B by inserting into the phospholipid monolayer at the alveolar surface. Its amphipathic structure allows it to facilitate the adsorption and spreading of phospholipids, stabilize the surfactant film during expiration, and prevent alveolar collapse (atelectasis). This action dramatically lowers surface tension, increases lung compliance, and improves gas exchange efficiency.
2.PRODUCT INDICATIONS
Neonatal Respiratory Distress Syndrome (RDS): For the prevention and treatment of RDS in premature infants.
Acute Respiratory Distress Syndrome (ARDS): As a therapeutic agent for improving oxygenation in adult patients with ARDS.
Surfactant Replacement Therapy: As a key active component in synthetic surfactant preparations.
3.CLINICAL EFFICACY OF PRODUCT
Clinical studies demonstrate that synthetic surfactant preparations containing Sinapultide significantly improve oxygenation (PaO2/FiO2 ratio), reduce the need for high ventilator pressures, and decrease the incidence of complications such as pneumothorax in premature infants with RDS. In adult ARDS, it has shown potential to improve lung compliance and gas exchange, contributing to reduced mortality and shorter duration of mechanical ventilation.
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