[Leu5]Enkephalin CAS NO.58822-25-6

[Leu⁵]Enkephalin (CAS No. 58822-25-6) is a synthetic pentapeptide with the molecular formula C₂₈H₃₇N₅O₇ and a molecular weight of 555.62 g/mol. It is a selective opioid receptor ligand widely used in neuroscience and pharmacology research, particularly in studies of pain modulation and neuroregulation.

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TECHNICAL SPECIFICATIONS

Item	Specification
Product Name	[Leu⁵]Enkephalin
CAS NO.	58822-25-6
Appearance	White to off-white lyophilized powder
Molecular Formula	C₂₈H₃₇N₅O₇
Molecular Weight	555.62g/mol
Amino Acid Sequence	Tyr-Gly-Gly-Phe-Leu
Purity (RP-HPLC)	≥98.0%
Solubility	Soluble in water, dimethyl sulfoxide (DMSO), and ethanol
Endotoxin	< 1.0 EU/mg
Biological Activity	Opioid receptor agonist; exhibits analgesic and neuroprotective effects in research models of pain and neurological disorders.
Storage Conditions	Store at –20°C, protected from light and moisture.
Stock Location	Stock in USA
MOQ	10mg

1.MECHANISM OF ACTION

[Leu⁵]Enkephalin acts as an endogenous opioid receptor agonist, primarily binding to delta (δ) and mu (μ) opioid receptors in the central and peripheral nervous systems. This interaction inhibits neurotransmitter release, reduces neuronal excitability, and modulates pain signaling pathways, contributing to its analgesic and neuroprotective effects.

2.PRODUCT INDICATIONS

This peptide is applied in research investigating opioid receptor function, pain mechanisms, stress response, and addiction. It is also used in experimental models of analgesia, neuroinflammation, and emotional behavior, supporting the development of novel therapeutic strategies for pain and neurological disorders.

3.CLINICAL EFFICACY OF PRODUCT

Preclinical studies have demonstrated that [Leu⁵]Enkephalin effectively reduces pain sensitivity in animal models and exhibits potential neuroprotective properties. While clinical translation is still under investigation, its efficacy in modulating pain pathways supports its relevance in developing targeted analgesic and neurotherapeutic agents.

4.DELIVERY & SHIPPING

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