Fibrinogen-binding Peptide CAS NO.137235-80-4

Fibrinogen-binding Peptide (FibP, CAS 137235-80-4) is a high-purity synthetic peptide designed to specifically target and bind to fibrinogen, a key glycoprotein in the blood coagulation cascade. This sequence is typically derived from the adhesive domains of proteins involved in hemostasis or thrombosis, such as a fragment of the γ-chain of fibrinogen. Manufactured under cGMP conditions, it serves as a critical research and diagnostic tool for studying thrombus formation, developing targeted therapeutics, and creating functional biomaterials that interact with the coagulation system.

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TECHNICAL SPECIFICATIONS

Item	Specification
Product Name	Fibrinogen-binding Peptide
CAS NO.	137235-80-4
Appearance	White to off-white lyophilized powder
Molecular Formula	C25H39N708
Molecular Weight	565.63g/mol
Purity (RP-HPLC)	≥ 98.0%
Solubility	Soluble in water, dilute acetic acid, and phosphate buffers; may require mild acid for complete dissolution
Endotoxin	< 1.0 EU/mg
Biological Activity	Binds to fibrinogen, inhibits platelet adhesion to fibrinogen and platelet aggregation, and also inhibits platelet adhesion to vitronectin.
Storage Conditions	Store at ≤-20°C (desiccated, sealed, away from moisture and light). -80°C for long-term storage (2 years), -20°C for short-term (1 month).
Stock Location	Stock in USA
MOQ	1g

1.MECHANISM OF ACTION

This peptide exerts its function by mimicking the natural binding sequence that mediates protein-protein interactions within the coagulation cascade. It specifically and with high affinity binds to fibrinogen molecules, particularly to sites like the platelet integrin receptor αIIbβ3 (GPIIb/IIIa) binding domain on the fibrinogen γ-chain.

2.PRODUCT INDICATIONS

Antithrombotic Drug Discovery: As a lead compound or screening tool for developing novel antiplatelet or anticoagulant agents.

Diagnostic Agent Development: For creating targeted imaging probes (e.g., for PET, SPECT, fluorescence) to visualize thrombi (blood clots) in vivo.

Biomaterial Functionalization: To coat medical devices (stents, grafts) or scaffolds to improve hemocompatibility or promote specific cell interactions.

Basic Coagulation Research: As a tool to study the molecular mechanisms of fibrinogen-mediated platelet aggregation and thrombus formation.

3.CLINICAL EFFICACY OF PRODUCT

As a research tool, FibP itself is not a clinically approved therapeutic. Its "efficacy" is measured in preclinical research settings. Studies show that peptides based on this sequence can effectively inhibit platelet aggregation in vitro and in animal models of thrombosis. When conjugated to imaging agents, they have demonstrated the ability to specifically localize to fresh and aged thrombi in experimental models, providing high-contrast imaging. The clinical success of related drugs (e.g., integrin αIIbβ3 antagonists like Tirofiban, which target the same interaction) validates the pathway this peptide modulates.

4.DELIVERY & SHIPPING

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Professional and Secure Packaging
Each bottle of peptide is protected with a special packaging solution to ensure stability and integrity during transportation.
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Shipping Methods
Main Method: International Air Freight

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