Fibrinogen β-Chain (24-42)
Fibrinogen β-Chain (24-42)
TECHNICAL SPECIFICATIONS
| Item | Specification |
|---|---|
| Product Name | Fibrinogen β-Chain (24-42) |
| CAS NO. | / |
| Appearance | White to off-white lyophilized powder |
| Molecular Formula | C₁₉₂H₂₈₉N₄₇O₆₁ |
| Molecular Weight | 4231.6 g/mol |
| Purity (RP-HPLC) | ≥ 95.0% |
| Solubility | Soluble in water, PBS (pH 7.0-7.5), dilute acetic acid; may require gentle sonication or mild acid for complete dissolution |
| Endotoxin | < 1.0 EU/mg |
| Biological Activity | Functional fragments of the fibrinogen β chain; involved in coagulation cascade reactions, platelet aggregation and inflammation regulation; often used to study its interaction with receptors such as integrins and selectins, and its role in thrombosis, wound repair and tumor metastasis. |
| Storage Conditions | Store at -20°C or below, protected from light and moisture. After reconstitution, aliquot and store at -20°C or -80°C; avoid repeated freeze-thaw cycles. |
| Stock Location | Stock in USA |
| MOQ | 1g |
1.MECHANISM OF ACTION
Fibrinogen β-Chain (24-42) functions by interacting with key receptors involved in coagulation and cellular adhesion, such as integrin αIIbβ3 (GPIIb/IIIa) and other fibrinogen-binding proteins. This interaction facilitates platelet aggregation, stabilizes fibrin clot formation, and modulates inflammatory responses. The peptide’s sequence corresponds to a functional domain critical for fibrin polymerization and cross-linking, influencing thrombus stability and resolution. Its role in signaling pathways also extends to endothelial and immune cell activation, contributing to vascular homeostasis and tissue repair processes.
2.PRODUCT INDICATIONS
- Coagulation Research: Studies on fibrinogen function, platelet aggregation, and thrombus formation
- Vascular Biology: Investigation of endothelial cell activation, vascular permeability, and angiogenesis
- Inflammation Studies: Research on fibrinogen-mediated inflammatory signaling and immune cell recruitment
- Drug Discovery: Screening for antithrombotic, anti-inflammatory, or antifibrotic therapeutic agents
- Disease Modeling: Tools for studying atherosclerosis, deep vein thrombosis, stroke, and other fibrinogen-related disorders
3.CLINICAL EFFICACY OF PRODUCT
- Research Reliability: Consistent performance in platelet aggregation assays, clot formation studies, and receptor binding experiments
- Biological Relevance: Validated role in mimicking native fibrinogen function in preclinical models
- High Purity: ≥95% HPLC purity with comprehensive characterization (mass spec, amino acid analysis)
- Experimental Versatility: Suitable for in vitro and in vivo studies of coagulation, inflammation, and vascular pathology
- Technical Support: Detailed protocols and activity data provided for seamless integration into research workflows
- Translational Potential: Aids in identifying novel biomarkers and therapeutic targets for thrombotic and inflammatory diseases
4.DELIVERY & SHIPPING
We specialize in global logistics for various cosmetic peptides. Your order will be handled with the utmost care, ensuring safe, reliable, and intact delivery.
Professional and Secure Packaging
Each bottle of peptide is protected with a special packaging solution to ensure stability and integrity during transportation.
We can also customize packaging according to customer needs.
Shipping Methods
Main Method: International Air Freight
We primarily use DHL, FedEx, UPS, and TNT because of their global reliability, speed, and advanced tracking systems. Air freight ensures the fastest transit time and minimizes the impact of environmental factors on the product.
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