Fibrinogen Binding Inhibitory Peptide CAS NO.89105-94-2
Fibrinogen Binding Inhibitory Peptide CAS NO.89105-94-2
TECHNICAL SPECIFICATIONS
| Item | Specification |
|---|---|
| Product Name | Fibrinogen Binding Inhibitory Peptide |
| CAS NO. | 89105-94-2 |
| Appearance | White to off-white lyophilized powder |
| Molecular Formula | C₅₀H₈₀N₁₈O₁₆ |
| Molecular Weight | 1189.29 g/mol |
| Purity (RP-HPLC) | ≥ 98.0% |
| Solubility | Soluble in water (pH 5.0–7.0) or PBS buffer; partially soluble in DMSO (≤10 mg/mL) |
| Endotoxin | < 1.0 EU/mg |
| Biological Activity | Potently inhibits fibrinogen binding to platelet integrin αIIbβ3 (GPIIb/IIIa) and endothelial receptors, reducing thrombus formation |
| Storage Conditions | Store at -20°C in a desiccated, light-protected container; avoid repeated freeze-thaw cycles. |
| Stock Location | Stock in USA |
| MOQ | 1g |
1.MECHANISM OF ACTION
This peptide selectively inhibits fibrinogen binding to key receptors:
Blocks interaction with platelet integrin αIIbβ3 (GPIIb/IIIa), preventing platelet aggregation.
Interferes with fibrinogen attachment to endothelial cell surface receptors, reducing thrombus formation.
Modulates coagulation cascade by limiting fibrin cross-linking, thereby stabilizing hemostatic balance.
2.PRODUCT INDICATIONS
Target applications include:
Thrombosis Research: Investigating arterial/venous clot formation mechanisms.
Anticoagulant Development: Preclinical testing of novel antiplatelet/antithrombotic drugs.
Platelet Function Studies: Analyzing fibrinogen’s role in hemostasis and vascular inflammation.
3.CLINICAL EFFICACY OF PRODUCT
In Vitro Studies: Inhibits platelet aggregation by 70–90% at 1–5 μM concentrations (vs. control).
Animal Models: Reduces thrombus size by 50–60% in carotid artery injury models (rat/mouse).
Safety Profile: Demonstrates low cytotoxicity and minimal bleeding risk in preclinical trials.
4.DELIVERY & SHIPPING
We specialize in global logistics for various cosmetic peptides. Your order will be handled with the utmost care, ensuring safe, reliable, and intact delivery.
Professional and Secure Packaging
Each bottle of peptide is protected with a special packaging solution to ensure stability and integrity during transportation.
We can also customize packaging according to customer needs.
Shipping Methods
Main Method: International Air Freight
We primarily use DHL, FedEx, UPS, and TNT because of their global reliability, speed, and advanced tracking systems. Air freight ensures the fastest transit time and minimizes the impact of environmental factors on the product.
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