Fibrinopeptide B, human CAS NO.36204-23-6

Fibrinopeptide B (human) (CAS 36204-23-6) is a high-purity synthetic tetradecapeptide (14-amino acid) representing the Bβ chain-derived cleavage fragment released from human fibrinogen by the action of thrombin during blood coagulation. This specific peptide serves as a critical biomarker and research tool. It is manufactured under stringent cGMP standards, offering a precise reagent for studying thrombin activity, fibrinolysis, and as a reference standard in diagnostic assays for thrombosis and hemostasis monitoring.

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TECHNICAL SPECIFICATIONS

Item	Specification
Product Name	Fibrinopeptide B, human
CAS NO.	36204-23-6
Appearance	White to off-white lyophilized powder
Molecular Formula	C66H93N19O25
Molecular Weight	1552.59g/mol
Purity (RP-HPLC)	≥ 98.0%
Solubility	Soluble in water (≥10 mg/mL), dilute acetic acid, or 0.1% TFA in aqueous solution
Endotoxin	< 1.0 EU/mg
Biological Activity	Modulates platelet aggregation and fibrin clot formation; can be used in coagulation assays to study fibrinogen cleavage
Storage Conditions	Store at -20°C to -80°C. Avoid repeated freeze-thaw cycles. Lyophilized product is stable for 24 months at -20°C.
Stock Location	Stock in USA
MOQ	1g

1.MECHANISM OF ACTION

Fibrinopeptide B is not an active therapeutic agent but a proteolytic byproduct with signaling roles. Its primary mechanism lies in its generation: Thrombin cleaves the Arg14-Gly15 bond on the Bβ chain of fibrinogen, releasing Fibrinopeptide B and exposing a new polymerization site (Gly-Pro-Arg).

2.PRODUCT INDICATIONS

Diagnostic Biomarker: As a calibrator and reference standard in ELISA and immunoassays to measure plasma Fibrinopeptide B levels, a sensitive indicator of in vivo thrombin generation and thrombotic activity.

Coagulation Research: As a specific substrate or product to study the kinetics and inhibition of thrombin, and to investigate fibrinogen-to-fibrin conversion.

Biochemical Reagent: For enzymatic studies, structure-activity relationship (SAR) analysis, and the development of novel anticoagulant therapies.

3.CLINICAL EFFICACY OF PRODUCT

As a diagnostic biomarker, elevated plasma levels of Fibrinopeptide B are clinically correlated with a hypercoagulable state and active thrombosis. Assays utilizing this peptide as a standard can accurately detect thrombin activity with high sensitivity. Monitoring Fibrinopeptide B levels is valuable in research and clinical settings for diagnosing conditions like deep vein thrombosis (DVT), disseminated intravascular coagulation (DIC), and assessing the efficacy of anticoagulant therapies (e.g., direct thrombin inhibitors). Its use improves diagnostic accuracy for thrombotic events.

4.DELIVERY & SHIPPING

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Main Method: International Air Freight

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