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Fibronectin Adhesion-Promoting Peptide CAS.125720-21-0

Fibronectin Adhesion-Promoting Peptide (also known as Heparin Binding Peptide, WQPPRARI) is a synthetic 8-amino acid peptide derived from the carboxy-terminal heparin-binding domain of fibronectin. This peptide sequence (Trp-Gln-Pro-Pro-Arg-Ala-Arg-Ile) exhibits potent cell adhesion-promoting properties by interacting with cell surface heparin sulfate proteoglycans and integrin receptors. It is widely used in cell culture applications, tissue engineering, and regenerative medicine research to enhance cell attachment, spreading, and migration of various cell types including endothelial cells, mesenchymal stem cells, and fibroblasts. The peptide is supplied as a white to off-white lyophilized powder with ≥95% purity and is soluble in water or PBS buffer.

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TECHNICAL SPECIFICATIONS

Item	Specification
Product Name	Fibronectin Adhesion-Promoting Peptide
CAS NO.	125720-21-0
Appearance	White to off-white lyophilized powder
Molecular Formula	C47H74N16O10
Molecular Weight	1023.22 g/mol
Purity (RP-HPLC)	≥ 95.0%
Solubility	Soluble in water (≥20 mg/mL), dilute PBS, or 0.1% TFA in aqueous solution.
Endotoxin	< 1.0 EU/mg
Biological Activity	Binds to integrin receptors (e.g., α₅β₁, αᵥβ₃) to promote cell adhesion, spreading, and migration; widely used in cell culture and tissue engineering.
Storage Conditions	Store at -20°C to -80°C. Lyophilized product is stable for 24 months at -20°C; avoid repeated freeze-thaw cycles.
Stock Location	Stock in USA
MOQ	1g

1.MECHANISM OF ACTION

The peptide functions through dual mechanisms: heparin sulfate proteoglycan (HSPG) binding and integrin-mediated signaling. The PRARI core sequence within the peptide (positions 4-7) binds to cell surface HSPGs, particularly syndecans, which act as co-receptors. This binding triggers intracellular signaling cascades involving focal adhesion kinase (FAK) and Src family kinases, leading to cytoskeletal reorganization and focal adhesion formation.

2.PRODUCT INDICATIONS

Cell Culture Enhancement: Coating culture surfaces to improve attachment and proliferation of primary cells (endothelial cells, mesenchymal stem cells, fibroblasts) that are difficult to culture

Tissue Engineering Scaffolds: Functionalization of biomaterials (hydrogels, polymer scaffolds) to promote cell infiltration and tissue integration

Wound Healing Models: In vitro studies of cell migration and extracellular matrix remodeling in wound repair assays

Stem Cell Research: Promoting aggregation and spheroid formation of mesenchymal stem cells for 3D culture applications

Angiogenesis Studies: Supporting endothelial cell tube formation and vascular network development in vitro

3.CLINICAL EFFICACY OF PRODUCT

In vitro studies show concentration-dependent enhancement of endothelial cell adhesion (up to 70% increase compared to uncoated surfaces) and migration in scratch wound assays

Animal models of skin wound healing demonstrate accelerated re-epithelialization and improved granulation tissue formation when peptide-functionalized dressings are applied

Bone regeneration studies in rodent defect models show improved osteogenic differentiation of mesenchymal stem cells when cultured on peptide-modified scaffolds

Cardiovascular applications indicate enhanced endothelialization of vascular grafts coated with this peptide sequence

4.DELIVERY & SHIPPING

We specialize in global logistics for various cosmetic peptides. Your order will be handled with the utmost care, ensuring safe, reliable, and intact delivery.
Professional and Secure Packaging
Each bottle of peptide is protected with a special packaging solution to ensure stability and integrity during transportation.
We can also customize packaging according to customer needs.
Shipping Methods
Main Method: International Air Freight

We primarily use DHL, FedEx, UPS, and TNT because of their global reliability, speed, and advanced tracking systems. Air freight ensures the fastest transit time and minimizes the impact of environmental factors on the product.