Fibronectin-Binding Protein

Fibronectin-Binding Protein is a high-molecular-weight protein with the molecular formula C₁₉₀H₂₈₃N₄₉O₆₆ and molecular weight 4309.66 g/mol. As a key mediator of host-pathogen interactions, it is widely studied for its role in bacterial adhesion and fibronectin-mediated signaling, making it indispensable for infectious disease research and anti-adhesion therapy development.

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TECHNICAL SPECIFICATIONS

Item	Specification
Product Name	Fibronectin-Binding Protein
CAS NO.	\
Appearance	White to off-white lyophilized powder
Molecular Formula	C₁₉₀H₂₈₃N₄₉O₆₆
Molecular Weight	4309.66 g/mol
Purity (RP-HPLC)	≥ 98.0%
Solubility	Soluble in neutral aqueous buffers (e.g., PBS, Tris-HCl pH 7.4); partially soluble in urea or guanidine hydrochloride (for denatured studies)
Endotoxin	< 1.0 EU/mg
Biological Activity	Mediates adhesion to host fibronectin matrices, facilitating pathogen colonization (e.g., bacterial biofilm formation, tissue invasion). Used to study host-pathogen interactions and fibronectin-mediated signaling.
Storage Conditions	Store at -80°C (long-term) or -20°C (short-term) in a desiccated, light-protected container; avoid repeated freeze-thaw cycles
Stock Location	Stock in USA
MOQ	1g

1.MECHANISM OF ACTION

Fibronectin-Binding Protein exerts its function through:

High-Affinity Fibronectin Binding: Contains specialized domains (e.g., FnBPA/FnBPB repeats) that recognize and bind to fibronectin’s RGD (Arg-Gly-Asp) and synergy sites, enabling strong adhesion to host extracellular matrices.

Pathogen Colonization: Facilitates bacterial attachment to host tissues (e.g., skin, mucosa), promoting colonization, biofilm formation, and resistance to mechanical clearance.

Signaling Modulation: Activates host cell pathways (e.g., integrin-FAK signaling) to trigger pro-inflammatory responses or modulate cell behavior, aiding pathogen survival.

2.PRODUCT INDICATIONS

This protein is critical for:

Infectious Disease Research: Studying bacterial pathogenesis (e.g., Staphylococcus aureus, Streptococcus pyogenes) and host-pathogen interaction mechanisms.

Anti-Adhesion Therapy Development: Screening compounds that block fibronectin binding to prevent bacterial colonization (e.g., anti-virulence drug discovery).

Biomaterial Compatibility Studies: Evaluating how implant surfaces interact with fibronectin and bacterial adhesins to design infection-resistant medical devices.

3.CLINICAL EFFICACY OF PRODUCT

In Vitro Studies: Demonstrates strong fibronectin binding (Kd ~10⁻⁹ M) and promotes bacterial adhesion to fibronectin-coated surfaces (2–5x increase vs. controls).

Animal Models: In murine wound infection models, Fibronectin-Binding Protein enhances S. aureuscolonization by 60–70%, validating its role in pathogenesis.

Therapeutic Potential: Blocking its fibronectin-binding domain reduces bacterial adhesion by 80% in vitro, supporting its use as a target for anti-adhesion therapies.

4.DELIVERY & SHIPPING

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Professional and Secure Packaging
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Shipping Methods
Main Method: International Air Freight

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