Fibronectin Type III Connecting Segment (1-25)

Fibronectin Type III Connecting Segment (1-25) is a high-purity synthetic peptide fragment derived from the extracellular matrix protein fibronectin. This bioactive 25-amino acid sequence corresponds to a functional domain critical for cell-matrix interactions, cellular adhesion, and tissue remodeling. Available as a white to off-white lyophilized powder with verified biological activity, it provides researchers with a reliable tool for studying integrin-mediated signaling, cellular migration, and tissue engineering applications. Manufactured under stringent quality controls, this peptide supports both basic research and translational studies in regenerative medicine, cancer biology, and wound healing.

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TECHNICAL SPECIFICATIONS

Item	Specification
Product Name	Fibronectin Type III Connecting Segment (1-25)
CAS NO.	/
Appearance	White to off-white lyophilized powder
Molecular Formula	C123H195N31O39
Molecular Weight	2732.11 g/mol
Purity (RP-HPLC)	≥ 95.0%
Solubility	Soluble in water, PBS (pH 7.0-7.5), dilute acetic acid
Endotoxin	< 1.0 EU/mg
Biological Activity	Functional fragments of fibronectin type III junctions; involved in cell adhesion, migration, signal transduction, and tissue repair; commonly used in integrin binding, cell-matrix interaction, wound healing, and tumor metastasis research.
Storage Conditions	Store at -20°C or below, protected from light and moisture. After reconstitution, aliquot and store at -20°C or -80°C
Stock Location	Stock in USA
MOQ	1g

1.MECHANISM OF ACTION

Fibronectin Type III Connecting Segment (1-25) functions by binding specifically to integrin receptors, particularly α4β1 (VLA-4) and α5β1, on cell surfaces. This interaction triggers intracellular signaling cascades involving focal adhesion kinase (FAK) and mitogen-activated protein kinases (MAPKs), promoting cell adhesion, spreading, and migration. The peptide competitively inhibits native fibronectin binding, enabling precise modulation of cell-matrix interactions in experimental models. Its conserved sequence within the CS-1 region of fibronectin ensures high-affinity receptor engagement and reproducible biological effects.

2.PRODUCT INDICATIONS

Cell Adhesion & Migration Studies: Investigation of integrin-mediated cellular behaviors in normal and pathological conditions

Tissue Engineering & Regenerative Medicine: Enhancement of scaffold bioactivity for improved cell attachment and tissue integration

Cancer Metastasis Research: Modeling of tumor cell invasion, extravasation, and metastatic niche formation

Inflammation & Immunology: Study of leukocyte trafficking, endothelial interactions, and inflammatory signaling

Drug Discovery & Development: Screening for anti-adhesive or pro-adhesive therapeutics targeting integrin pathways

3.CLINICAL EFFICACY OF PRODUCT

Research Validation: Demonstrated efficacy in promoting cell adhesion, migration, and signaling in peer-reviewed studies

High Purity: ≥95% purity by RP-HPLC with mass spectrometry confirmation of sequence and molecular weight

Functional Activity: Validated in cell-based adhesion assays, migration assays, and integrin binding studies

Reproducibility: Consistent batch-to-batch performance with comprehensive Certificate of Analysis (CoA)

Translational Potential: Supports development of biomimetic materials, anti-metastatic agents, and regenerative therapies

Quality Assurance: Manufactured under GLP-like conditions with low endotoxin levels for in vitro and in vivo applications

4.DELIVERY & SHIPPING

We specialize in global logistics for various cosmetic peptides. Your order will be handled with the utmost care, ensuring safe, reliable, and intact delivery.
Professional and Secure Packaging
Each bottle of peptide is protected with a special packaging solution to ensure stability and integrity during transportation.
We can also customize packaging according to customer needs.
Shipping Methods
Main Method: International Air Freight

We primarily use DHL, FedEx, UPS, and TNT because of their global reliability, speed, and advanced tracking systems. Air freight ensures the fastest transit time and minimizes the impact of environmental factors on the product.