Galanin, rat CAS NO.114547-31-8

Galanin, rat (CAS NO. 114547-31-8) is a 29-amino-acid neuropeptide with the molecular formula C₁₄₁H₂₁₁N₄₃O₄₁ and molecular weight 3164.48 g/mol. As a key regulator of neurotransmission and homeostasis, it is widely studied for its roles in pain modulation, feeding behavior, and stress responses, making it indispensable for neuroscience research and drug development.

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TECHNICAL SPECIFICATIONS

Item	Specification
Product Name	Galanin, rat
CAS NO.	114547-31-8
Appearance	White to off-white lyophilized powder
Molecular Formula	C₁₄₁H₂₁₁N₄₃O₄₁
Molecular Weight	3164.48 g/mol
Purity (RP-HPLC)	≥ 98.0%
Solubility	Soluble in water (pH 4.0–7.0) or 0.1 M acetic acid; slightly soluble in DMSO (≤5 mg/mL)
Endotoxin	< 1.0 EU/mg
Biological Activity	Binds to galanin receptors (GALR1, GALR2, GALR3) with high affinity; modulates neurotransmission, pain perception, feeding behavior, and stress responses. Used to study neuroendocrine regulation and develop analgesics/anti-obesity drugs.
Storage Conditions	Store at -20°C in a desiccated, light-protected container; avoid repeated freeze-thaw cycles.
Stock Location	Stock in USA
MOQ	1g

1.MECHANISM OF ACTION

Galanin Receptor Activation: Binds to three G protein-coupled receptors (GALR1, GALR2, GALR3) with high affinity (Ki: 0.1–5 nM), inhibiting adenylate cyclase and modulating intracellular calcium levels.

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Neurotransmitter Modulation: Inhibits acetylcholine release in the hippocampus, dopamine release in the striatum, and noradrenaline release in the hypothalamus, altering synaptic plasticity.

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Hypothalamic Regulation: Acts on the arcuate nucleus to suppress appetite and regulate energy balance via NPY/AgRP and POMC/CART pathways.

2.PRODUCT INDICATIONS

Neuroscience Research: Studying depression, anxiety, epilepsy, and neurodegenerative diseases (e.g., Alzheimer’s, Parkinson’s).

Pain Management Studies: Investigating its antinociceptive effects in acute and chronic pain models (e.g., neuropathic, inflammatory pain).

Metabolic Disorder Research: Exploring its role in obesity, anorexia, and diabetes via hypothalamic feeding regulation.

3.CLINICAL EFFICACY OF PRODUCT

Reduces pain responses by 40–60% in rodent models of neuropathic pain (spinal nerve ligation).

Decreases food intake by 30–50% in diet-induced obese rats, improving insulin sensitivity.

Attenuates anxiety-like behaviors in mice (elevated plus maze test) by 50–70%.

4.DELIVERY & SHIPPING

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Main Method: International Air Freight

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