Galanin, human CAS NO.119418-04-1

Galanin, human (CAS: 119418-04-1) is a 30-amino acid neuropeptide that functions as a neuromodulator and neurotransmitter in the central and peripheral nervous systems. This peptide is synthesized as a precursor (preprogalanin) and processed to the mature form, which exhibits high affinity for galanin receptors (GalR1, GalR2, GalR3). It is involved in various physiological processes including appetite regulation, nociception, cognition, and neuroendocrine functions. The synthetic human galanin peptide is supplied as a white lyophilized powder with ≥95% purity, soluble in water or aqueous buffers, and is widely used in neuroscience research, receptor binding studies, and functional assays.

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TECHNICAL SPECIFICATIONS

Item	Specification
Product Name	Galanin, human
CAS NO.	119418-04-1
Appearance	White to off-white lyophilized powder
Molecular Formula	C139H210N42O43
Molecular Weight	3157.44 g/mol
Purity (RP-HPLC)	≥ 95.0%
Solubility	Soluble in water (≥10 mg/mL), dilute acetic acid or DMSO
Endotoxin	< 1.0 EU/mg
Biological Activity	Potently activates galanin receptors (GALR1, GALR2, GALR3); induces intracellular calcium mobilization in receptor-expressing cells.
Storage Conditions	Store at -20°C to -80°C; avoid repeated freeze-thaw cycles. Reconstituted solution can be stored at 4°C for up to 1 week or at -20°C for up to 3 months.
Stock Location	Stock in USA
MOQ	1g

1.MECHANISM OF ACTION

Galanin exerts its biological effects primarily through G protein-coupled receptor (GPCR) activation. The peptide binds to three known galanin receptor subtypes (GalR1, GalR2, GalR3) with nanomolar affinity. GalR1 and GalR3 couple to Gi/o proteins, leading to inhibition of adenylate cyclase, reduction of cAMP levels, and inhibition of voltage-gated calcium channels. GalR2 primarily couples to Gq/11 proteins, activating phospholipase C (PLC), increasing intracellular calcium, and stimulating protein kinase C (PKC).

2.PRODUCT INDICATIONS

Neuroscience Research: Studying galaninergic signaling in learning, memory, and cognitive function

Receptor Binding Assays: Radioligand binding studies and receptor autoradiography for GalR1, GalR2, GalR3

Appetite Regulation Studies: Investigating galanin's role in feeding behavior and energy homeostasis

Pain and Nociception Research: Evaluating galanin's modulatory effects on pain pathways

Neuroendocrine Studies: Assessing galanin's effects on hormone secretion (prolactin, growth hormone)

Cell Signaling Studies: Investigating intracellular signaling pathways activated by galanin receptors

Drug Discovery: Screening compounds targeting galanin receptors for therapeutic development

3.CLINICAL EFFICACY OF PRODUCT

Animal studies demonstrate that galanin administration stimulates feeding behavior and modulates pain sensitivity in various pain models

Human genetic studies suggest associations between galanin gene polymorphisms and conditions like Alzheimer's disease, depression, and eating disorders

Early-phase clinical trials with galanin receptor ligands (agonists/antagonists) have been conducted for conditions including epilepsy, depression, and obesity, but results are preliminary

A small clinical study in patients with temporal lobe epilepsy showed altered galanin levels in cerebrospinal fluid, suggesting potential biomarker utility

No approved therapeutics based on galanin or its analogs are currently available; most clinical research remains in exploratory phases

4.DELIVERY & SHIPPING

We specialize in global logistics for various cosmetic peptides. Your order will be handled with the utmost care, ensuring safe, reliable, and intact delivery.
Professional and Secure Packaging
Each bottle of peptide is protected with a special packaging solution to ensure stability and integrity during transportation.
We can also customize packaging according to customer needs.
Shipping Methods
Main Method: International Air Freight

We primarily use DHL, FedEx, UPS, and TNT because of their global reliability, speed, and advanced tracking systems. Air freight ensures the fastest transit time and minimizes the impact of environmental factors on the product.