Galanin (1-16), porcine, rat CAS NO.125118-77-6

Galanin (1-16), porcine, rat is a high-purity synthetic peptide fragment corresponding to the N-terminal 1-16 sequence of native galanin. This bioactive peptide retains key receptor-binding domains, making it a valuable research tool for studying galanin receptor signaling and neuroendocrine modulation. Available as a white to off-white lyophilized powder with HPLC-verified purity, it ensures reliable performance in neuroscience, endocrinology, and behavioral research applications. Ideal for both in vitro and in vivo studies, this peptide provides researchers with a specific and reproducible means to explore galanin-mediated physiological processes.

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TECHNICAL SPECIFICATIONS

Item	Specification
Product Name	Galanin (1-16), porcine, rat
CAS NO.	2805997-46-8
Appearance	White to off-white lyophilized powder
Molecular Formula	C78H116N20O21
Molecular Weight	1669.92 g/mol
Purity (RP-HPLC)	≥ 95.0%
Solubility	Soluble in water, dilute acetic acid, DMSO
Endotoxin	< 1.0 EU/mg
Biological Activity	Galanin receptor agonists (primarily acting on GalR1/GalR2) have activities such as inhibiting neurotransmitter release, regulating appetite, and affecting memory and pain perception.
Storage Conditions	Store at -20°C, protected from light and moisture. After reconstitution, aliquot and store at -20°C.
Stock Location	Stock in USA
MOQ	1g

1.MECHANISM OF ACTION

Galanin (1-16) functions as a selective agonist for galanin receptors, primarily GalR1 and GalR2. By binding to these G-protein coupled receptors, it modulates intracellular signaling pathways such as inhibition of adenylate cyclase and regulation of potassium and calcium channels. This leads to reduced neurotransmitter release (e.g., acetylcholine, glutamate), altered neuronal excitability, and downstream effects on hormone secretion, feeding behavior, and nociceptive processing, mimicking the activity of the full-length galanin peptide in a receptor-subtype selective manner.

2.PRODUCT INDICATIONS

Neuroscience Research: Investigation of synaptic transmission, learning, memory, anxiety, and neuroprotection

Endocrine Studies: Research on insulin and growth hormone secretion, and metabolic regulation

Pain and Nociception: Study of galanin’s role in modulating pain pathways and inflammatory responses

Feeding and Metabolism: Exploration of appetite control, energy homeostasis, and obesity-related mechanisms

Drug Discovery: Screening and development of galanin receptor-targeted therapeutics for neurological and metabolic disorders

3.CLINICAL EFFICACY OF PRODUCT

Validated Bioactivity: Demonstrated receptor binding and functional activity in cellular and animal models

High Purity: ≥95% by RP-HPLC with mass spectrometry confirmation of sequence and molecular weight

Reproducible Results: Consistent performance in neurotransmitter release assays, hormone studies, and behavioral tests

Research Flexibility: Suitable for receptor binding studies, signal transduction analysis, and in vivo behavioral experiments

Quality Assurance: Manufactured under controlled conditions with low endotoxin levels for research applications

Translational Utility: Supports preclinical research on epilepsy, diabetes, chronic pain, and neurodegenerative diseases

4.DELIVERY & SHIPPING

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Professional and Secure Packaging
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Shipping Methods
Main Method: International Air Freight

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