Galanin (1-13)-Neuropeptide Y (25-36), amide (M32) CAS NO.147138-51-0

Galanin (1-13)-Neuropeptide Y (25-36), amide (M32) (CAS NO. 147138-51-0) is a chimeric neuropeptide with the molecular formula C₁₃₆H₂₀₉N₄₁O₃₄ and molecular weight 2962.4 g/mol. Engineered to combine functional domains of galanin (1-13) and neuropeptide Y (25-36), it serves as a dual-target tool for neuroscience research and multi-receptor therapeutic development.

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TECHNICAL SPECIFICATIONS

Item	Specification
Product Name	Galanin (1-13)-Neuropeptide Y (25-36), amide (M32)
CAS NO.	147138-51-0
Appearance	White to off-white lyophilized powder
Molecular Formula	C₁₃₆H₂₀₉N₄₁O₃₄
Molecular Weight	2962.4 g/mol
Purity (RP-HPLC)	≥ 98.0%
Solubility	Soluble in water (pH 4.0–7.0) or 0.1 M acetic acid; slightly soluble in DMSO (≤5 mg/mL)
Endotoxin	< 1.0 EU/mg
Biological Activity	Chimeric neuropeptide combining galanin (1-13) and neuropeptide Y (25-36) moieties. Binds to both galanin receptors (GALR1/2/3) and neuropeptide Y receptors (Y1/Y2/Y5) with high affinity, modulating neurotransmission, feeding behavior, and stress responses. Used to study receptor crosstalk and develop dual-action therapeutics.
Storage Conditions	Lyophilized powder: Store at -20°C in a desiccated, light-protected container; avoid repeated freeze-thaw cycles. After reconstitution, aliquot and store at -80°C (stable for 6 months) or 2–8°C (stable for 1 week).
Stock Location	Stock in USA
MOQ	1g

1.MECHANISM OF ACTION

Dual Receptor Binding: Binds to galanin receptors (GALR1/2/3, Ki: 0.5–5 nM) and neuropeptide Y receptors (Y1/Y2/Y5, Ki: 1–10 nM), modulating overlapping signaling pathways (e.g., cAMP inhibition, Ca²⁺ flux).

Neurotransmitter Regulation: Inhibits acetylcholine release in the hippocampus (galanin activity) and enhances GABAergic transmission in the hypothalamus (neuropeptide Y activity), balancing synaptic plasticity.

Appetite/Stress Crosstalk: Suppresses orexigenic NPY/AgRP signals and activates anorexigenic POMC neurons via Y1/Y5 receptors, while galanin-mediated GALR1 activation reduces stress-induced corticosterone release.

2.PRODUCT INDICATIONS

Neuroscience Research: Studying receptor crosstalk in depression, obesity, and epilepsy, where both galanin and NPY systems are dysregulated.

Multi-Target Drug Development: Screening dual-action agonists/antagonists for treating metabolic disorders (e.g., obesity) and neuropsychiatric conditions (e.g., anxiety).

Behavioral Studies: Investigating feeding behavior, pain perception, and stress responses in rodent models using tagged or fluorescently labeled variants.

3.CLINICAL EFFICACY OF PRODUCT

Reduces food intake by 40–60% in diet-induced obese mice (dual Y1/Y5 and GALR1 activation).

Therapeutic Potential: Early-stage studies suggest M32 analogs may outperform single-target peptides in managing comorbid obesity and depression.

4.DELIVERY & SHIPPING

We specialize in global logistics for various cosmetic peptides. Your order will be handled with the utmost care, ensuring safe, reliable, and intact delivery.
Professional and Secure Packaging
Each bottle of peptide is protected with a special packaging solution to ensure stability and integrity during transportation.
We can also customize packaging according to customer needs.
Shipping Methods
Main Method: International Air Freight

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