Gastrin-1, human ( Gastrin17) CAS NO.10047-33-3
TECHNICAL SPECIFICATIONS
| Item | Specification |
|---|---|
| Product Name | Gastrin-1, human (Gastrin 17) |
| CAS NO. | 10047-33-3 |
| Appearance | White to off-white lyophilized powder |
| Molecular Formula | C97H125N20O31S |
| Molecular Weight | 2098.22g/mol |
| Amino Acid Sequence | Pyr-Gly-Pro-Trp-Leu-Glu-Glu-Glu-Glu-Glu-Ala-Tyr-Gly-Trp-Met-Asp-Phe-NH₂ (Pyr = pyroglutamic acid) |
| Purity (RP-HPLC) | ≥95.0% (can be customized to ≥98.0%) |
| Solubility | Soluble in water, dilute acetic acid solution, and aqueous buffers |
| Endotoxin | <1.0 eu=""> |
| Biological Activity | Stimulates gastric acid secretion and mucosal cell growth; used in gastrointestinal physiology, cancer, and ulcer research. |
| Storage Conditions | Store at –20°C, protected from light and moisture. |
| Stock Location | Stock in USA |
| MOQ | 1mg |
1.MECHANISM OF ACTION
Gastrin-1, human (Gastrin 17) functions by binding to cholecystokinin-2 receptors (CCK2R) on gastric parietal cells, stimulating the release of gastric acid through intracellular calcium and protein kinase signaling pathways. It also promotes the growth and proliferation of gastric mucosal cells, contributing to the maintenance of gastrointestinal integrity.
2.PRODUCT INDICATIONS
This peptide is used in research focused on gastric physiology, peptic ulcer disease, gastrointestinal cancers, and diagnostic assays for gastrin-related disorders. It is also applied in studies of hormone secretion, cell proliferation, and the development of therapeutic agents targeting acid-related gastrointestinal conditions.
3.CLINICAL EFFICACY OF PRODUCT
Clinical and preclinical studies have demonstrated that Gastrin-1, human (Gastrin 17) effectively stimulates gastric acid secretion and supports mucosal repair in experimental models. Its role as a biomarker and therapeutic target in conditions like Zollinger-Ellison syndrome and gastric adenocarcinoma underscores its relevance in translational gastrointestinal research.
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