english

[Leu15]-Gastrin I (human) CAS NO.39024-57-2

[Leu15]-Gastrin I (human) is a synthetic analog of the human gastrin hormone, specifically characterized by the substitution of methionine at position 15 with leucine. This peptide is a 17-amino acid variant corresponding to the biologically active C-terminal fragment of gastrin. The methionine-to-leucine substitution enhances chemical stability by removing the oxidation-prone sulfur-containing amino acid, making it a more robust tool for experimental applications.

Send Email

Download

TECHNICAL SPECIFICATIONS

Item	Specification
Product Name	[Leu¹⁵]-Gastrin I (human)
CAS NO.	39024-57-2
Appearance	White to off-white lyophilized powder
Molecular Formula	C98H126N20O31
Molecular Weight	2080.19g/mol
Purity (RP-HPLC)	≥ 95.0%
Solubility	Soluble in water (≥ 5 mg/mL), dilute acetic acid, and DMSO; forms a clear solution at 1 mg/mL in wate
Endotoxin	< 1.0 EU/mg
Biological Activity	Potent stimulator of gastric acid secretion, comparable to native gastrin I EC₅₀ ≤ 5 nM in parietal cell functional assays Resists degradation by serum enzymes longer than native gastrin.
Storage Conditions	Store at -20°C to -80°C in a desiccated, inert atmosphere Avoid repeated freeze-thaw cycles; aliquot into single-use portions
Stock Location	Stock in USA
MOQ	1g

1.MECHANISM OF ACTION

[Leu15]-Gastrin I functions as a potent agonist for the cholecystokinin B/gastrin receptor (CCK₂R). The peptide binds specifically to this G protein-coupled receptor located predominantly on gastric parietal cells and enterochromaffin-like (ECL) cells. Receptor activation triggers the Gq/11 signaling pathway, leading to phospholipase C (PLC) activation. This results in the production of inositol trisphosphate (IP₃) and diacylglycerol (DAG), which subsequently increase intracellular calcium levels and activate protein kinase C (PKC).

2.PRODUCT INDICATIONS

Gastrointestinal Physiology Studies: Investigating the mechanisms of gastric acid secretion, parietal cell function, and gastrin signaling pathways.

Receptor Pharmacology: Serving as a stable reference agonist in CCK₂ receptor binding assays, signal transduction studies, and drug screening.

Method Development: Utilized in the development and validation of in vitroassays for gastric function due to its enhanced chemical stability compared to native gastrin.

Comparative Studies: Comparing the biological activity and stability of modified versus native gastrin peptides.

Trophic Effect Research: Studying the role of gastrin in the growth and maintenance of gastrointestinal mucosa and certain tumor cells.

3.CLINICAL EFFICACY OF PRODUCT

Research Validation: In vitroand animal studies confirm that this analog retains the acid-stimulating potency of native human gastrin-I, making it a validated tool for physiological research.

Stability Advantage: The primary advantage over native gastrin is its resistance to oxidation, which improves reproducibility in long-term experiments and assay protocols.

Diagnostic/Therapeutic Gap: While the gastrin/CCK₂R pathway is clinically relevant (e.g., in diagnosing gastrinoma), this specific analog is not used in clinical diagnostics or therapy. Its role is confined to preclinical research.

Translational Relevance: Research using this stable analog contributes to the broader understanding of gastrin biology, which indirectly informs the development of clinical diagnostic tests (e.g., for Zollinger-Ellison syndrome) and therapeutic strategies targeting acid-related disorders.

4.DELIVERY & SHIPPING

We specialize in global logistics for various cosmetic peptides. Your order will be handled with the utmost care, ensuring safe, reliable, and intact delivery.
Professional and Secure Packaging
Each bottle of peptide is protected with a special packaging solution to ensure stability and integrity during transportation.
We can also customize packaging according to customer needs.
Shipping Methods
Main Method: International Air Freight

We primarily use DHL, FedEx, UPS, and TNT because of their global reliability, speed, and advanced tracking systems. Air freight ensures the fastest transit time and minimizes the impact of environmental factors on the product.