Gastrin I (rat) CAS NO.81123-06-0

Gastrin I (Rat) (CAS 81123-06-0) is the predominant 17-amino acid, non-sulfated isoform of the gastrin hormone specifically isolated from or synthesized to match rat species. This peptide contains the C-terminal tetrapeptide amide sequence (Trp-Met-Asp-Phe-NH₂) which is essential for biological activity and receptor binding. It plays a critical role in stimulating gastric acid secretion and mucosal growth in rodent physiology. Supplied as a high-purity (>95%) lyophilized powder, it is soluble in aqueous buffers or dilute acetic acid and is a vital reagent for species-specific gastrointestinal and endocrine research using rat models.

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TECHNICAL SPECIFICATIONS

Item	Specification
Product Name	Gastrin I (rat) (Rat Gastrin-17)
CAS NO.	81123-06-0
Appearance	White to off-white lyophilized solid powder
Molecular Formula	C94H128N22O31S2
Molecular Weight	2126.3g/mol
Purity (RP-HPLC)	≥98.0%
Solubility	Soluble in DMSO (≥27.5 mg/mL), water, and dilute aqueous acids.
Endotoxin	≤5.0 EU/mg
Biological Activity	Potent stimulator of gastric acid secretion; binds to cholecystokinin B (CCK2) receptors to induce histamine release and gastric motility.
Storage Conditions	-20°C to -80°C (sealed, away from moisture and light). Stable for 1 year at -20°C, 2 years at -80°C. Avoid repeated freeze-thaw cycles.
Stock Location	Stock in USA
MOQ	1g

1.MECHANISM OF ACTION

Gastrin I (Rat) exerts its biological effects by binding and activating the cholecystokinin-B/gastrin receptor (CCK₂R or CCKBR), a G protein-coupled receptor highly expressed on gastric parietal cells and enterochromaffin-like (ECL) cells in the stomach. The binding event triggers Gq/11 protein activation, leading to phospholipase C (PLC) stimulation. This results in the hydrolysis of phosphatidylinositol 4,5-bisphosphate (PIP₂) into inositol trisphosphate (IP₃) and diacylglycerol (DAG).

2.PRODUCT INDICATIONS

Rodent Gastrointestinal Physiology: Studying the regulation of gastric acid secretion, mucosal growth, and gastrointestinal motility in rats.

Species-Specific Hormone Research: Investigating the structure-function relationship and signaling of gastrin in rat tissues and cell lines.

In VivoModeling: Administering to rats to create models of hypergastrinemia, investigate acid-related disorders, or study gastrin's trophic effects.

In VitroReceptor Studies: Serving as the native ligand for CCK₂R in binding assays, autoradiography, and functional studies using rat-derived tissues or cells.

Drug Discovery & Pharmacology: Testing the efficacy of gastrin receptor antagonists or acid-suppressing drugs in rat-based assay systems.

Comparative Endocrinology: Comparing biological activity and receptor affinity across different species (rat vs. human vs. mouse gastrin).

3.CLINICAL EFFICACY OF PRODUCT

Research Validation: Its efficacy is well-established in rat physiology. Studies show it potently stimulates gastric acid secretion and induces mucosal hyperplasia in rats, making it a standard tool for creating experimental models.
Translation to Human Health: Research using this peptide in rat models has been fundamental in understanding the pathophysiology of conditions like Zollinger-Ellison syndrome, peptic ulcers, and gastric cancer, informing human clinical strategies.
Diagnostic/Therapeutic Gap: The peptide itself is not used as a drug or diagnostic in humans. Its value lies entirely in generating preclinical data.
Regulatory Status: It is not an approved therapeutic agent. Any future human drug development targeting the gastrin pathway would involve human-specific analogs or receptor modulators, not the rat peptide.

4.DELIVERY & SHIPPING

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Professional and Secure Packaging
Each bottle of peptide is protected with a special packaging solution to ensure stability and integrity during transportation.
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Shipping Methods
Main Method: International Air Freight

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