TECHNICAL SPECIFICATIONS
Item
| Specification
|
|---|
Product Name
| Gastrin I (1-14) (human)
|
CAS NO.
| 100940-57-6 |
Appearance
| White to off-white lyophilized powder
|
Molecular Formula
| C79H100N16O27
|
Molecular Weight
| 1705.76 g/mol |
Purity (RP-HPLC)
| ≥ 95.0% |
Solubility
| Soluble in water, acetic acid (0.1%), DMSO; may require gentle vortexing or sonication |
| Endotoxin | < 1.0 EU/mg
|
Biological Activity
| Gastrin/cholecystokinin-B receptor agonist; stimulates gastric acid secretion and mucosal growth.
|
Storage Conditions
| Store at -20°C or below, protected from light and moisture. After reconstitution, aliquot and store at -20°C.
|
Stock Location
| Stock in USA
|
MOQ
| 1g |
1.MECHANISM OF ACTION
Gastrin I (1-14) (human) binds with high affinity to gastrin/CCK-B receptors on gastric parietal cells and other target tissues. This binding activates G-protein coupled signaling pathways, leading to increased intracellular calcium mobilization and activation of protein kinase C. The downstream effects include stimulation of gastric acid secretion, promotion of gastric mucosal cell proliferation, and modulation of gastrointestinal motility. Unlike full-length gastrin, this fragment retains receptor-binding activity while offering specificity for mechanistic studies of receptor-ligand interactions.
2.PRODUCT INDICATIONS
Gastrointestinal Research: Investigation of gastric acid secretion, mucosal growth, and gut hormone regulation
Receptor Pharmacology: Study of gastrin/CCK-B receptor signaling, binding affinity, and receptor subtype specificity
Drug Discovery: Screening and development of gastrin receptor agonists or antagonists for therapeutic applications
Metabolic Studies: Exploration of gastrin's role in appetite regulation, nutrient absorption, and metabolic disorders
Cell Signaling Research: Analysis of intracellular signaling pathways activated by gastrin receptor stimulation
3.CLINICAL EFFICACY OF PRODUCT
Validated Bioactivity: Demonstrated receptor binding and functional activity in gastric acid secretion assays and cell-based models
High Purity: ≥95% by RP-HPLC with mass spectrometry confirmation of sequence and molecular weight
Reproducible Performance: Consistent results in receptor binding studies, acid secretion experiments, and signaling pathway analysis
Research Versatility: Suitable for in vitro cell culture studies, ex vivo tissue preparations, and in vivo animal models
Quality Assurance: Produced under controlled conditions with low endotoxin levels for research applications
Translational Relevance: Supports preclinical research on peptic ulcer disease, Zollinger-Ellison syndrome, and gastrointestinal cancers
4.DELIVERY & SHIPPING
We specialize in global logistics for various cosmetic peptides. Your order will be handled with the utmost care, ensuring safe, reliable, and intact delivery.
Professional and Secure Packaging
Each bottle of peptide is protected with a special packaging solution to ensure stability and integrity during transportation.
We can also customize packaging according to customer needs.
Shipping Methods
Main Method: International Air Freight
We primarily use DHL, FedEx, UPS, and TNT because of their global reliability, speed, and advanced tracking systems. Air freight ensures the fastest transit time and minimizes the impact of environmental factors on the product.
