Ghrelin (human) CAS NO.258279-04-8

Ghrelin (human) (CAS NO. 258279-04-8) is a 28-amino-acid peptide hormone with the molecular formula C₁₄₉H₂₄₉N₄₇O₄₂ and molecular weight 3370.9 g/mol. As the only known endogenous ligand of the growth hormone secretagogue receptor 1a (GHS-R1a), it is a key regulator of appetite, growth hormone (GH) secretion, and energy metabolism, making it indispensable for endocrinology, metabolism, and obesity research.

Send Email

Download

TECHNICAL SPECIFICATIONS

Item	Specification
Product Name	Ghrelin (human)
CAS NO.	258279-04-8
Appearance	White to off-white lyophilized powder
Molecular Formula	C₁₄₉H₂₄₉N₄₇O₄₂
Molecular Weight	3370.9 g/mol
Purity (RP-HPLC)	≥ 98.0%
Solubility	Freely soluble in deionized water (pH 4.0–7.0) or 0.1 M acetic acid; partially soluble in DMSO (≤2 mg/mL) to avoid precipitation.
Endotoxin	< 1.0 EU/mg
Biological Activity	Endogenous ligand of the growth hormone secretagogue receptor 1a (GHS-R1a; human, Ki: 0.1–1 nM). Stimulates growth hormone (GH) release from the pituitary, increases appetite via hypothalamic NPY/AgRP pathway activation, and modulates energy metabolism, stress responses, and gut motility. O-acyl modification (e.g., octanoylation at Ser³) is critical for activity.
Storage Conditions	Store at -20°C in a tightly sealed, light-protected container; avoid moisture and repeated freeze-thaw cycles.
Stock Location	Stock in USA
MOQ	1g

1.MECHANISM OF ACTION

GHS-R1a Activation: Binds to the growth hormone secretagogue receptor 1a (GHS-R1a) with high affinity (human, Ki: 0.1–1 nM), triggering Gq/11 protein-coupled signaling cascades.

Appetite Stimulation: Crosses the blood-brain barrier to activate hypothalamic orexigenic neurons (NPY/AgRP pathway), increasing hunger and food intake.

GH Secretion: Stimulates growth hormone release from the anterior pituitary gland via GHS-R1a-mediated Ca²⁺ influx and cAMP elevation.

Metabolic Regulation: Modulates energy balance by promoting adipogenesis, reducing fat oxidation, and influencing glucose metabolism.

2.PRODUCT INDICATIONS

Appetite & Obesity Research: Studying hyperphagia, satiety regulation, and metabolic disorders (e.g., obesity, cachexia).

Endocrine Studies: Investigating GH deficiency, acromegaly, and age-related hormonal changes.

Preclinical Drug Development: Screening GHS-R1a agonists/antagonists for treating eating disorders, growth disorders, or metabolic diseases.

3.CLINICAL EFFICACY OF PRODUCT

Preclinical Validation:

Increases food intake by 40–60% in fasted rodent models (ED₅₀: 0.3 nM).

Stimulates GH release by 3–5x in human pituitary cell cultures (concentration: 1 nM).

Promotes weight gain in cachectic animal models (20–30% increase over controls).

Therapeutic Potential: GHS-R1a antagonists derived from ghrelin are in clinical trials for obesity, while agonists show promise for GH deficiency therapy.

4.DELIVERY & SHIPPING

We specialize in global logistics for various cosmetic peptides. Your order will be handled with the utmost care, ensuring safe, reliable, and intact delivery.
Professional and Secure Packaging
Each bottle of peptide is protected with a special packaging solution to ensure stability and integrity during transportation.
We can also customize packaging according to customer needs.
Shipping Methods
Main Method: International Air Freight

We primarily use DHL, FedEx, UPS, and TNT because of their global reliability, speed, and advanced tracking systems. Air freight ensures the fastest transit time and minimizes the impact of environmental factors on the product.