GHRF (1-44), human CAS NO.83930-13-6
GHRF (1-44), human CAS NO.83930-13-6
TECHNICAL SPECIFICATIONS
| Item | Specification |
|---|---|
| Product Name | GHRF (1-44), human (Growth Hormone-Releasing Factor (1-44), human. |
| CAS NO. | 83930-13-6 |
| Appearance | White to off-white lyophilized powder |
| Molecular Formula | C215H358N72O66S |
| Molecular Weight | 5039.7g/mol |
| Purity (RP-HPLC) | ≥98.0% |
| Solubility | Soluble in water (≥5 mg/mL), dilute acetic acid, and DMSO |
| Endotoxin | < 1.0 EU/mg |
| Biological Activity | Potent agonist of the growth hormone-releasing hormone receptor (GHRHR) |
| Storage Conditions | Store at -20°C to -80°C in a sealed container, protected from moisture and light. |
| Stock Location | Stock in USA |
| MOQ | 1g |
1.MECHANISM OF ACTION
GHRF (1-44) exerts its biological effect by binding and activating the Growth Hormone-Releasing Hormone Receptor (GHRHR) on somatotroph cells in the anterior pituitary. GHRHR is a G-protein coupled receptor (GPCR) primarily coupled to the Gs protein. Upon binding, it stimulates adenylate cyclase activity, leading to a significant increase in intracellular cyclic adenosine monophosphate (cAMP) levels.
- Endocrinology Research: Studying the hypothalamic-pituitary axis, pulsatile GH secretion, and feedback regulation mechanisms in vitroand in vivo.
- Pituitary Cell Studies: Using primary pituitary cell cultures or somatotroph cell lines to investigate GH synthesis and secretion dynamics.
- Receptor Pharmacology: Serving as the native, high-affinity ligand in GHRHR binding assays, signal transduction studies, and for evaluating receptor antagonists.
- Animal Models: Administering to laboratory animals to stimulate GH secretion for studies on growth, metabolism, and body composition.
- Diagnostic Tool Development: Acting as a reference standard in the development of assays to measure GHRH or to assess pituitary reserve and function (though synthetic analogs like Tesamorelin are more common in clinical diagnostics).
- Structure-Function Studies: Serving as the baseline molecule for comparing the activity of shorter fragments or modified analogs.
2.PRODUCT INDICATIONS
- Physiological Role: It is the natural stimulator of GH secretion. Its efficacy in stimulating GH release is well-documented in both animal and human physiological studies.
- Therapeutic Analogs: The understanding of GHRF's action led to the development of stable analogs. Tesamorelin, a synthetic analog of GHRH(1-44), is FDA-approved for treating HIV-associated lipodystrophy. Other analogs have been investigated for conditions like growth hormone deficiency.
- Diagnostic Use: GHRF and its analogs have been used in diagnostic tests (GHRH stimulation tests) to assess pituitary function and differentiate the origin of growth hormone deficiency (pituitary vs. hypothalamic).
- Research Relevance: While the native peptide has limited direct clinical use, it remains the critical reference compound for research that underpins the development of all related diagnostics and therapeutics targeting the GHRH pathway.
3.CLINICAL EFFICACY OF PRODUCT
4.DELIVERY & SHIPPING
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Shipping Methods
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