GHRF, mouse (Growth Hormone-Releasing Factor, mouse)
GHRF, mouse (Growth Hormone-Releasing Factor, mouse)
TECHNICAL SPECIFICATIONS
| Item | Specification |
|---|---|
| Product Name | GHRF, mouse (Growth Hormone-Releasing Factor, mouse) |
| CAS NO. | 2805997-46-8 |
| Appearance | White to off-white lyophilized powder |
| Molecular Formula | C220H365N69O64S |
| Molecular Weight | 5032.85 g/mol |
| Purity (RP-HPLC) | ≥ 95.0% |
| Solubility | Soluble in water, acetic acid (0.1%), DMSO; may require gentle vortexing |
| Endotoxin | < 1.0 EU/mg |
| Biological Activity | Growth hormone-releasing hormone (GHRH) analog; stimulates growth hormone secretion from pituitary somatotrophs via GHRH receptor activation. |
| Storage Conditions | Store at -20°C or below, protected from light and moisture. After reconstitution, aliquot and store at -20°C |
| Stock Location | Stock in USA |
| MOQ | 1g |
1.MECHANISM OF ACTION
GHRF, mouse binds with high affinity to GHRH receptors on pituitary somatotroph cells, activating G-protein coupled signaling pathways. This binding stimulates adenylate cyclase activity, increasing intracellular cAMP levels and activating protein kinase A (PKA). The downstream effects include phosphorylation of transcription factors (such as CREB), enhanced growth hormone gene expression, and stimulation of growth hormone synthesis and secretion. The peptide exhibits species specificity for mouse GHRH receptors, making it particularly valuable for mouse-based research models of growth and endocrine function.
2.PRODUCT INDICATIONS
Endocrine Research: Investigation of growth hormone regulation, pituitary function, and growth axis signaling in mouse models
Metabolic Studies: Research on growth hormone's role in metabolism, body composition, and energy homeostasis
Animal Model Development: Use in mouse models of growth hormone deficiency, dwarfism, and metabolic disorders
Drug Discovery: Screening for GHRH receptor agonists or antagonists for therapeutic applications
Receptor Pharmacology: Study of GHRH receptor binding, signal transduction, and receptor subtype specificity
Preclinical Studies: Evaluation of growth-promoting effects and endocrine system modulation in mouse systems
3.CLINICAL EFFICACY OF PRODUCT
Validated Bioactivity: Demonstrated potent stimulation of growth hormone secretion in mouse pituitary cells and in vivo models
High Purity: ≥95% by RP-HPLC with mass spectrometry confirmation of sequence and C-terminal amidation
Species Specificity: Optimized for mouse GHRH receptors, ensuring reliable results in mouse-based research
Research Reproducibility: Consistent performance in growth hormone release assays, receptor binding studies, and animal experiments
Quality Assurance: Produced under controlled conditions with low endotoxin levels for research applications
Translational Relevance: Supports preclinical research on growth disorders, metabolic diseases, and endocrine therapeutics using mouse models
Documentation: Each batch includes Certificate of Analysis with purity, mass spec, and biological activity data
4.DELIVERY & SHIPPING
We specialize in global logistics for various cosmetic peptides. Your order will be handled with the utmost care, ensuring safe, reliable, and intact delivery.
Professional and Secure Packaging
Each bottle of peptide is protected with a special packaging solution to ensure stability and integrity during transportation.
We can also customize packaging according to customer needs.
Shipping Methods
Main Method: International Air Freight
We primarily use DHL, FedEx, UPS, and TNT because of their global reliability, speed, and advanced tracking systems. Air freight ensures the fastest transit time and minimizes the impact of environmental factors on the product.
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