TECHNICAL SPECIFICATIONS
Item
| Specification
|
|---|
Product Name
| Growth Hormone Releasing Factor, GRF (1-40), amide, humanGrowth Hormone Releasing Factor, GRF (1-40), amide, human
|
CAS NO.
| / |
Appearance
| White to off-white lyophilized powder
|
Molecular Formula
| C194H318N62O62S
|
Molecular Weight
| 4543.14 g/mol |
Purity (RP-HPLC)
| ≥ 95.0% |
Solubility
| Soluble in water, acetic acid (0.1%), and DMSO; may require gentle vortexing for complete dissolution |
| Endotoxin | < 1.0 EU/mg
|
Biological Activity
| Growth hormone-releasing hormone (GHRH) agonist; stimulates growth hormone secretion from anterior pituitary somatotrophs via activation of GHRH receptor.
|
Storage Conditions
| Store at -20°C or below, protected from light and moisture. After reconstitution, aliquot and store at -20°C
|
Stock Location
| Stock in USA
|
MOQ
| 1g |
1.MECHANISM OF ACTION
Growth Hormone Releasing Factor, GRF (1-40), amide, human binds with high affinity to GHRH receptors on pituitary somatotroph cells, activating G-protein coupled signaling pathways. This binding stimulates adenylate cyclase activity, increasing intracellular cAMP levels and activating protein kinase A (PKA). The downstream effects include phosphorylation of transcription factors (such as CREB), enhanced growth hormone gene expression, and stimulation of growth hormone synthesis and secretion. The C-terminal amidation enhances peptide stability and receptor binding affinity, while the human sequence ensures optimal activity in human cell-based systems and translational research models.
2.PRODUCT INDICATIONS
Endocrine Research: Investigation of growth hormone regulation, pituitary function, and growth axis signaling in human cell models
Metabolic Studies: Research on growth hormone's role in metabolism, body composition, and energy homeostasis using human systems
Drug Discovery: Screening for GHRH receptor agonists or antagonists for therapeutic applications targeting human receptors
Receptor Pharmacology: Study of GHRH receptor binding, signal transduction, and receptor subtype specificity in human models
Preclinical Studies: Evaluation of growth-promoting effects and endocrine system modulation in human cell-based assays
Translational Research: Bridge between basic research and clinical applications using human-specific peptide sequences
3.CLINICAL EFFICACY OF PRODUCT
Validated Bioactivity: Demonstrated potent stimulation of growth hormone secretion in human pituitary cells and cell-based assays
High Purity: ≥95% by RP-HPLC with mass spectrometry confirmation of sequence and C-terminal amidation
Human Sequence Specificity: Optimized for human GHRH receptors, ensuring reliable results in human cell-based research and translational studies
Research Reproducibility: Consistent performance in growth hormone release assays, receptor binding studies, and cell-based experiments
Quality Assurance: Produced under controlled conditions with low endotoxin levels for research applications
Translational Relevance: Supports preclinical research on growth disorders, metabolic diseases, and endocrine therapeutics using human-relevant models
Documentation: Each batch includes Certificate of Analysis with purity, mass spec, and biological activity data
4.DELIVERY & SHIPPING
We specialize in global logistics for various cosmetic peptides. Your order will be handled with the utmost care, ensuring safe, reliable, and intact delivery.
Professional and Secure Packaging
Each bottle of peptide is protected with a special packaging solution to ensure stability and integrity during transportation.
We can also customize packaging according to customer needs.
Shipping Methods
Main Method: International Air Freight
We primarily use DHL, FedEx, UPS, and TNT because of their global reliability, speed, and advanced tracking systems. Air freight ensures the fastest transit time and minimizes the impact of environmental factors on the product.
