Gastric Inhibitory Peptide (GIP), human CAS NO.100040-31-1

Gastric Inhibitory Peptide (GIP), human is a high-purity synthetic peptide corresponding to the 42-amino acid sequence of human glucose-dependent insulinotropic polypeptide. This bioactive peptide functions as a key incretin hormone, stimulating insulin secretion in a glucose-dependent manner and regulating gastric acid secretion and lipid metabolism. With HPLC-verified purity and comprehensive analytical documentation, it provides researchers with a reliable tool for studying incretin physiology, diabetes mechanisms, and metabolic disorders. Ideal for both in vitro and in vivo applications, this peptide ensures consistent performance in diabetes research, drug discovery, and metabolic disease studies.

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TECHNICAL SPECIFICATIONS

Item	Specification
Product Name	Gastric Inhibitory Peptide (GIP), human
CAS NO.	100040-31-1
Appearance	White to off-white lyophilized powder
Molecular Formula	C226H338N60O66S
Molecular Weight	4983.64g/mol
Purity (RP-HPLC)	≥ 95.0%
Solubility	Soluble in water, acetic acid (0.1%), and DMSO; may require gentle vortexing for complete dissolution
Endotoxin	< 1.0 EU/mg
Biological Activity	Glucose-dependent insulinotropic polypeptide; stimulates insulin secretion, inhibits gastric acid secretion, and promotes lipid metabolism.
Storage Conditions	Store at -20°C or below, protected from light and moisture. After reconstitution, aliquot and store at -20°C
Stock Location	Stock in USA
MOQ	1g

1.MECHANISM OF ACTION

Gastric Inhibitory Peptide (GIP), human binds with high affinity to GIP receptors on pancreatic beta cells, adipocytes, and other target tissues, activating G-protein coupled signaling pathways. This binding stimulates adenylate cyclase activity, increasing intracellular cAMP levels and activating protein kinase A (PKA). In pancreatic beta cells, this leads to enhanced insulin secretion in a glucose-dependent manner. Additionally, GIP inhibits gastric acid secretion, promotes glucagon secretion under hypoglycemic conditions, and modulates lipid metabolism in adipose tissue. The peptide exhibits full biological activity and species specificity for human GIP receptors, making it valuable for human-relevant research models.

2.PRODUCT INDICATIONS

Diabetes Research: Investigation of incretin physiology, insulin secretion regulation, and beta cell function in human models

Metabolic Studies: Research on GIP's role in glucose homeostasis, lipid metabolism, and energy balance

Drug Discovery: Screening for GIP receptor agonists, antagonists, or DPP-4 inhibitors for diabetes therapeutics

Gastrointestinal Research: Study of gastric acid secretion regulation and gut hormone interactions

Obesity Research: Investigation of GIP's effects on adipocyte function and lipid storage

Preclinical Studies: Evaluation of metabolic effects and safety profiles in human cell-based systems

3.CLINICAL EFFICACY OF PRODUCT

Validated Bioactivity: Demonstrated potent stimulation of insulin secretion in pancreatic beta cells and glucose-dependent incretin effects

High Purity: ≥95% by RP-HPLC with mass spectrometry confirmation of sequence and C-terminal amidation

Species Specificity: Optimized for human GIP receptors, ensuring reliable results in human cell-based research

Research Reproducibility: Consistent performance in insulin secretion assays, receptor binding studies, and metabolic experiments

Quality Assurance: Produced under controlled conditions with low endotoxin levels for research applications

Translational Relevance: Supports preclinical research on diabetes, metabolic disorders, and incretin-based therapeutics

Documentation: Each batch includes Certificate of Analysis with purity, mass spec, and biological activity data

4.DELIVERY & SHIPPING

We specialize in global logistics for various cosmetic peptides. Your order will be handled with the utmost care, ensuring safe, reliable, and intact delivery.
Professional and Secure Packaging
Each bottle of peptide is protected with a special packaging solution to ensure stability and integrity during transportation.
We can also customize packaging according to customer needs.
Shipping Methods
Main Method: International Air Freight

We primarily use DHL, FedEx, UPS, and TNT because of their global reliability, speed, and advanced tracking systems. Air freight ensures the fastest transit time and minimizes the impact of environmental factors on the product.