GIP, mouse, rat
TECHNICAL SPECIFICATIONS
| Item | Specification |
|---|---|
| Product Name | Gastric Inhibitory Polypeptide (GIP), rat |
| CAS NO. | |
| Appearance | White to off-white lyophilized powder |
| Molecular Formula | C226H343N61O66S |
| Molecular Weight | 5002.69g/mol |
| Amino Acid Sequence | H-Tyr-Ala-Glu-Gly-Thr-Phe-Ile-Ser-Asp-Tyr-Ser-Ile-Ala-Met-Asp-Lys-Ile-His-Gln-Gln-Asp-Phe-Val-Asn-Trp-Leu-Leu-Ala-Gln-Lys-Gly-Lys-Lys-Asn-Asp-Trp-Lys-His-Asn-Ile-Thr-Gln-OH (rat GIP₁₋₄₂) |
| Purity (RP-HPLC) | ≥95.0% |
| Solubility | Soluble in distilled water (up to 2 mg/mL) and acetonitrile |
| Endotoxin | ≤1.0 EU/mg |
| Biological Activity | Potent incretin hormone that stimulates glucose-dependent insulin secretion from pancreatic β-cells via GIP receptor activation; used in metabolic and diabetes research, as well as in the development of incretin-based therapies. |
| Storage Conditions | Store at –20°C, protected from light and moisture. For long-term storage, recommend –80°C. |
| Stock Location | Stock in USA |
| MOQ | 10mg |
1.MECHANISM OF ACTION
GIP (Rat) exerts its effects by binding to the GIP receptor (GIPR), a G protein-coupled receptor (GPCR) expressed on pancreatic β-cells and other tissues. This binding activates adenylyl cyclase, increasing intracellular cAMP levels, which in turn stimulates insulin secretion in a glucose-dependent manner. GIP also activates pathways such as MAPK, phospholipase A2, and PI3K/Akt, contributing to its diverse metabolic effects.
2.PRODUCT INDICATIONS
GIP (Rat) is primarily used in scientific research to study glucose metabolism, insulin secretion, and the incretin effect in rodent models. It is also employed in the development and validation of diagnostic assays for metabolic disorders, such as diabetes and obesity, and in the evaluation of incretin-based therapeutic strategies.
3.CLINICAL EFFICACY OF PRODUCT
Preclinical studies in rodent models have demonstrated that GIP (Rat) effectively enhances glucose-dependent insulin secretion, improves glucose tolerance, and promotes β-cell proliferation. It also exhibits effects on adipose tissue, bone metabolism, and neuroprotection, highlighting its potential therapeutic relevance in metabolic and neurological disorders.
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