GIP (3 – 42), human

GIP (3-42), human is a synthetic peptide fragment derived from the human Gastric Inhibitory Polypeptide (GIP), representing the amino acid sequence from position 3 to 42. This peptide is designed for research on incretin hormone signaling, glucose metabolism, and receptor interaction studies. It is supplied as a high-purity lyophilized powder, manufactured under stringent quality controls to ensure consistent performance in biochemical and cellular assays. The product is ideal for investigating the structure-function relationships of GIP, studying metabolic pathways, and developing diagnostic or therapeutic applications related to diabetes and obesity.

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TECHNICAL SPECIFICATIONS

Item	Specification
Product Name	GIP (3 – 42), human
CAS NO.	1802086-25-4
Appearance	White to off-white lyophilized powder
Molecular Formula	C214H324N58O63S
Molecular Weight	4749.38g/mol
Purity (RP-HPLC)	≥ 95.0%
Solubility	Soluble in water, acetic acid (0.1%), and DMSO
Endotoxin	< 1.0 EU/mg
Biological Activity	It is an N-terminal truncated form of GIP, which may retain some GIP receptor binding activity, but its activity is usually lower than that of the full-length GIP (1-42); it is often used as a negative control or structure-function analysis in receptor binding, signal transduction and metabolism studies.
Storage Conditions	Store at -20°C or below, protected from light and moisture. After reconstitution, aliquot and store at -20°C.
Stock Location	Stock in USA
MOQ	1g

1.MECHANISM OF ACTION

GIP (3-42), human acts as a truncated form of the full-length GIP hormone, which normally binds to the GIP receptor (GIPR) on pancreatic beta cells and adipocytes. This binding stimulates insulin secretion in a glucose-dependent manner and influences lipid metabolism. While the N-terminal truncation may alter receptor affinity and signaling efficacy, GIP (3-42) is commonly used to study receptor-ligand interactions, downstream signaling pathways (e.g., cAMP/PKA activation), and the functional role of specific GIP domains in metabolic regulation.

2.PRODUCT INDICATIONS

Metabolic Research: Study of glucose homeostasis, insulin secretion, and incretin physiology.

Receptor Pharmacology: Investigation of GIP receptor binding, activation, and signal transduction mechanisms.

Drug Discovery: Screening for GIPR agonists/antagonists or modulators of incretin-based therapies.

Diabetes & Obesity Models: Use in cellular or animal models to explore GIP’s role in metabolic diseases.

Structural Biology: Analysis of peptide-receptor interactions and domain-specific functions.

3.CLINICAL EFFICACY OF PRODUCT

Research Reliability: High batch-to-batch consistency and ≥95% purity verified by RP-HPLC.

Functional Relevance: Demonstrates measurable receptor binding and signaling activity in validated assay systems.

Experimental Flexibility: Suitable for in vitro binding studies, cell-based functional assays, and preclinical metabolic research.

Quality Assurance: Manufactured under GMP-like conditions with low endotoxin levels and full analytical documentation (CoA provided).

Translational Utility: Supports the development of GIP-targeted diagnostics and therapeutics for metabolic disorders.

4.DELIVERY & SHIPPING

We specialize in global logistics for various cosmetic peptides. Your order will be handled with the utmost care, ensuring safe, reliable, and intact delivery.
Professional and Secure Packaging
Each bottle of peptide is protected with a special packaging solution to ensure stability and integrity during transportation.
We can also customize packaging according to customer needs.
Shipping Methods
Main Method: International Air Freight

We primarily use DHL, FedEx, UPS, and TNT because of their global reliability, speed, and advanced tracking systems. Air freight ensures the fastest transit time and minimizes the impact of environmental factors on the product.