Glucagon (1 – 29), bovine, human, porcine CAS NO.16941-32-5

Glucagon (1 – 29), derived from bovine, human, and porcine sources, is a peptide hormone with significant physiological implications. Its unique molecular structure, characterized by the formula C₁₅₃H₂₂₅N₄₃O₄₉S and a molecular weight of 3482.78, enables it to play a crucial role in glucose metabolism regulation.

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TECHNICAL SPECIFICATIONS

Item	Specification
Product Name	Glucagon (1 – 29), bovine, human, porcine
CAS NO.	16941 – 32 – 5
Appearance	White to off-white lyophilized powder
Molecular Formula	C215H357N71O67S
Molecular Weight	3482.78g/mol
Purity (RP-HPLC)	≥98%
Solubility	Soluble in water
Endotoxin	≤1.0 EU/mg
Biological Activity	Glucagon (1 – 29) exhibits the characteristic biological activity of glucagon, which includes stimulating glycogenolysis (the breakdown of glycogen to glucose) and gluconeogenesis (the synthesis of glucose from non – carbohydrate sources) in the liver, thereby increasing blood glucose levels. In in vitro assays using liver cell lines or isolated hepatocytes
Storage Conditions	tore at – 20°C in a dry environment, protected from light. Avoid repeated freeze – thaw cycles to maintain its stability and biological activity.
Stock Location	Stock in USA
MOQ	1g

1.MECHANISM OF ACTION

Glucagon (1 – 29) primarily acts on the liver cells. It binds to specific glucagon receptors on the surface of these cells, triggering a cascade of intracellular signaling pathways. This activation stimulates glycogenolysis, the breakdown of glycogen into glucose, releasing it into the bloodstream. Additionally, it promotes gluconeogenesis, the synthesis of glucose from non – carbohydrate precursors such as amino acids and glycerol. These processes collectively lead to an elevation in blood glucose levels.

2.PRODUCT INDICATIONS

Research Applications: Widely used in biological and medical research laboratories to study glucose metabolism disorders, such as diabetes. It helps researchers understand the normal physiological regulation of blood sugar levels and the pathophysiology of diabetes – related conditions.

Potential Therapeutic Exploration: Although not yet a mainstream therapeutic agent, Glucagon (1 – 29) shows promise in the exploration of novel treatments for hypoglycemic disorders. It can be used to counteract severe hypoglycemia in certain clinical scenarios where rapid elevation of blood glucose is required.

3.CLINICAL EFFICACY OF PRODUCT

In pre – clinical studies involving animal models of diabetes, Glucagon (1 – 29) has demonstrated the ability to effectively restore normal blood glucose levels when administered in appropriate doses. It has been shown to reverse the hypoglycemic state induced by excessive insulin administration, highlighting its potential as an anti – hypoglycemic agent. However, further large – scale clinical trials are needed to fully establish its long – term safety and efficacy in human patients.

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