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GLP-2 (1-34) (human)

GLP-2 (1-34) (human) is a high-purity synthetic peptide corresponding to the full-length 34-amino acid sequence of human glucagon-like peptide-2. This bioactive peptide functions as a key intestinal growth factor, promoting mucosal proliferation, enhancing nutrient absorption, and maintaining intestinal barrier integrity. Manufactured under stringent quality controls with HPLC-verified purity and comprehensive analytical documentation, it provides researchers with a reliable tool for studying intestinal physiology, gut repair mechanisms, and metabolic disorders. Ideal for both in vitro and in vivo applications, this peptide ensures consistent performance in gastrointestinal research, drug discovery, and therapeutic development for intestinal diseases.

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TECHNICAL SPECIFICATIONS

Item	Specification
Product Name	GLP-2 (1-34) (human)
CAS NO.	/
Appearance	White to off-white lyophilized powder
Molecular Formula	C171H266N48O56S
Molecular Weight	3922.38 g/mol
Purity (RP-HPLC)	≥ 95.0%
Solubility	Soluble in water, acetic acid (0.1%), PBS (pH 7-8); gentle sonication may be necessary to aid dissolution.
Endotoxin	< 1.0 EU/mg
Biological Activity	Glucagon-like peptide-2 promotes intestinal growth, repair, and barrier function, inhibits intestinal epithelial cell apoptosis, and increases nutrient absorption.
Storage Conditions	Store at -20°C or below, protected from light and moisture. After reconstitution, aliquot and store at -20°C.
Stock Location	Stock in USA
MOQ	1g

1.MECHANISM OF ACTION

GLP-2 (1-34) (human) binds specifically to the GLP-2 receptor (GLP-2R) expressed on intestinal epithelial cells and enteric neurons. This binding activates G-protein coupled signaling pathways, primarily increasing intracellular cAMP levels and activating protein kinase A (PKA). Downstream effects include stimulation of crypt cell proliferation, inhibition of enterocyte apoptosis, enhancement of nutrient transporter expression, and promotion of intestinal blood flow. The peptide also modulates gut barrier function by increasing tight junction protein expression. GLP-2 exhibits species specificity for human GLP-2 receptors, making it particularly valuable for human-relevant research models and preclinical studies.

2.PRODUCT INDICATIONS

Gastrointestinal Research: Investigation of intestinal mucosal growth, repair mechanisms, and barrier function

Metabolic Studies: Research on nutrient absorption, gut hormone interactions, and metabolic regulation

Drug Discovery: Screening for GLP-2 receptor agonists or analogs for treating intestinal disorders

Inflammatory Bowel Disease Models: Study of GLP-2 effects in Crohn's disease, ulcerative colitis, and other gut pathologies

Short Bowel Syndrome Research: Evaluation of therapeutic potential in intestinal adaptation and regeneration

Preclinical Development: Assessment of pharmacokinetics, efficacy, and safety in animal models

3.CLINICAL EFFICACY OF PRODUCT

Validated Bioactivity: Demonstrated potent stimulation of intestinal epithelial cell proliferation and crypt cell growth in validated assay systems

High Purity: ≥95% by RP-HPLC with mass spectrometry confirmation of sequence and molecular weight

Species Specificity: Optimized for human GLP-2 receptors, ensuring reliable results in human cell-based research

Research Reproducibility: Consistent performance in cell proliferation assays, receptor binding studies, and animal models

Quality Assurance: Produced under controlled conditions with low endotoxin levels for research applications

Translational Relevance: Supports preclinical research on intestinal diseases, short bowel syndrome, and GLP-2-based therapeutics

Documentation: Each batch includes Certificate of Analysis with purity, mass spec, and biological activity data

4.DELIVERY & SHIPPING

We specialize in global logistics for various cosmetic peptides. Your order will be handled with the utmost care, ensuring safe, reliable, and intact delivery.
Professional and Secure Packaging
Each bottle of peptide is protected with a special packaging solution to ensure stability and integrity during transportation.
We can also customize packaging according to customer needs.
Shipping Methods
Main Method: International Air Freight

We primarily use DHL, FedEx, UPS, and TNT because of their global reliability, speed, and advanced tracking systems. Air freight ensures the fastest transit time and minimizes the impact of environmental factors on the product.