GLP-1 (9-36) amide (human, bovine, guinea pig, mouse, porcine, rat) CAS NO.161748-29-4

GLP-1 (9-36) amide (human, bovine, guinea pig, mouse, porcine, rat) is a multi-species collection of synthetic peptide fragments representing the major N-terminally truncated metabolite of glucagon-like peptide-1. This 28-amino acid peptide (C-terminal amide form) is available across multiple mammalian species, providing researchers with species-matched tools for comparative metabolic studies. The peptide exhibits weak GLP-1 receptor activity and serves as a valuable tool for investigating GLP-1 metabolism, clearance mechanisms, and receptor modulation. Supplied as high-purity lyophilized powder with HPLC-verified quality and species-specific sequence confirmation, this product enables cross-species research in diabetes, metabolism, and incretin biology.

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TECHNICAL SPECIFICATIONS

Item	Specification
Product Name	GLP-1 (9-36) amide (human, bovine, guinea pig, mouse, porcine, rat)
CAS NO.	161748-29-4
Appearance	White to off-white lyophilized powder
Molecular Formula	C140H214N36O43
Molecular Weight	3089.48g/mol
Purity (RP-HPLC)	≥ 95.0%
Solubility	Soluble in water, acetic acid (0.1%), PBS (pH 7-8)
Endotoxin	< 1.0 EU/mg
Biological Activity	Low-affinity ligands/weak antagonists of the GLP-1 receptor; potentially involved in the regulation of glucose homeostasis, and important metabolites for studying GLP-1 metabolism and clearance.
Storage Conditions	Store at -20°C or below, protected from light and moisture. After reconstitution, aliquot and store at -20°C
Stock Location	Stock in USA
MOQ	1g

1.MECHANISM OF ACTION

GLP-1 (9-36) amide acts as a low-affinity ligand for the GLP-1 receptor, functioning primarily as a weak antagonist or partial agonist. This peptide is generated in vivo through N-terminal cleavage of active GLP-1 (7-36) by dipeptidyl peptidase-4 (DPP-4), representing the major circulating metabolite. While it binds to GLP-1 receptors with significantly reduced affinity compared to the full-length peptide, it may modulate receptor signaling and contribute to the overall incretin effect. The C-terminal amidation enhances peptide stability and may influence receptor interaction. This product allows researchers to study species-specific differences in GLP-1 metabolism, receptor binding kinetics, and the physiological role of GLP-1 metabolites in glucose homeostasis.

2.PRODUCT INDICATIONS

Comparative Species Studies: Investigation of species-specific differences in GLP-1 metabolism and receptor pharmacology

Metabolic Research: Study of GLP-1 clearance mechanisms, DPP-4 activity, and incretin degradation pathways

Receptor Pharmacology: Evaluation of GLP-1 receptor binding affinity, signal transduction, and antagonist properties

Diabetes Research: Exploration of GLP-1 metabolite effects on glucose homeostasis and insulin secretion

Preclinical Development: Use in species-matched animal models for metabolic and pharmacokinetic studies

Cross-Species Validation: Comparison of peptide activity across human and common laboratory animal species

3.CLINICAL EFFICACY OF PRODUCT

Species Coverage: Available for human, bovine, guinea pig, mouse, porcine, and rat, enabling comprehensive cross-species research

High Purity: ≥95% by RP-HPLC with mass spectrometry confirmation of species-specific sequences

Sequence Accuracy: Each species variant verified for correct amino acid sequence and C-terminal amidation

Research Utility: Validated for receptor binding studies, metabolic assays, and species comparison experiments

Quality Documentation: Certificate of Analysis provided for each batch with purity, mass spec, and species identification

Technical Support: Access to species-specific application guidance and experimental design consultation

4.DELIVERY & SHIPPING

We specialize in global logistics for various cosmetic peptides. Your order will be handled with the utmost care, ensuring safe, reliable, and intact delivery.
Professional and Secure Packaging
Each bottle of peptide is protected with a special packaging solution to ensure stability and integrity during transportation.
We can also customize packaging according to customer needs.
Shipping Methods
Main Method: International Air Freight

We primarily use DHL, FedEx, UPS, and TNT because of their global reliability, speed, and advanced tracking systems. Air freight ensures the fastest transit time and minimizes the impact of environmental factors on the product.