[Des-His1, Glu9] – Glucagon (1 – 29), amide CASNO.110084-95-2

[Des-His1, Glu9] – Glucagon (1-29), amide is a synthetic glucagon analog featuring two key modifications: deletion of the N-terminal histidine residue (Des-His1) and substitution of position 9 with glutamic acid (Glu9), with C-terminal amidation. These structural alterations significantly modify the peptide's receptor binding properties, potentially converting it into a glucagon receptor antagonist or partial agonist. This high-purity peptide is designed for investigating glucagon receptor pharmacology, studying receptor-ligand interactions, and exploring metabolic regulation pathways. Manufactured under stringent quality controls with HPLC-verified purity and comprehensive analytical documentation, it provides researchers with a precise tool for glucagon signaling research and metabolic disorder studies.

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TECHNICAL SPECIFICATIONS

Item	Specification
Product Name	[Des-His1, Glu9] – Glucagon (1-29), amide
CAS NO.	110084-95-2
Appearance	White to off-white lyophilized powder
Molecular Formula	C148H221N41O47S
Molecular Weight	3358.72g/mol
Purity (RP-HPLC)	≥ 98.0%
Solubility	Soluble in water, dilute acetic acid, DMSO; gentle solubilization may be required.
Endotoxin	< 1.0 EU/mg
Biological Activity	Glucagon analogues, modified with [Des-His1] and [Glu9], may alter their affinity and selectivity for glucagon receptors and are often used in receptor subtype studies, signal transduction mechanism exploration, and diabetes metabolism research.
Storage Conditions	Store at -20°C or below, protected from light and moisture. After reconstitution, aliquot and store at -20°C
Stock Location	Stock in USA
MOQ	1g

1.MECHANISM OF ACTION

[Des-His1, Glu9] – Glucagon (1-29), amide interacts with glucagon receptors (GCGR) but exhibits altered binding affinity and signaling properties compared to native glucagon. The deletion of His1 (critical for receptor activation) typically results in significantly reduced or abolished agonistic activity, potentially converting the peptide into a competitive antagonist or weak partial agonist. The Glu9 substitution may further modulate receptor interaction, potentially affecting receptor subtype selectivity or metabolic stability. This modified peptide can competitively inhibit native glucagon binding, allowing researchers to study receptor occupancy, signal transduction mechanisms, and the physiological effects of glucagon receptor blockade. It may also serve as a tool to investigate allosteric modulation or receptor internalization processes.

2.PRODUCT INDICATIONS

Receptor Pharmacology: Investigation of glucagon receptor binding kinetics, affinity, and competitive inhibition studies

Metabolic Research: Study of glucagon signaling pathways in glucose homeostasis and hepatic metabolism

Diabetes Research: Evaluation of glucagon receptor antagonism effects on hyperglycemia and metabolic disorders

Structure-Activity Relationship Studies: Exploration of how specific amino acid modifications affect receptor interaction

Signal Transduction: Analysis of cAMP/PKA pathway modulation and downstream signaling events

Preclinical Development: Assessment of glucagon receptor antagonists for therapeutic applications

3.CLINICAL EFFICACY OF PRODUCT

High Purity: ≥95% by RP-HPLC with mass spectrometry confirmation of sequence and modifications

Structural Validation: Precise verification of Des-His1 deletion and Glu9 substitution by analytical methods

Research Reliability: Consistent performance in receptor binding assays and functional studies

Quality Documentation: Each batch includes Certificate of Analysis with purity, mass spec, and amino acid analysis data

Technical Support: Access to expert consultation on glucagon receptor research applications

Custom Synthesis Capability: Support for additional modifications or bulk quantities

4.DELIVERY & SHIPPING

We specialize in global logistics for various cosmetic peptides. Your order will be handled with the utmost care, ensuring safe, reliable, and intact delivery.
Professional and Secure Packaging
Each bottle of peptide is protected with a special packaging solution to ensure stability and integrity during transportation.
We can also customize packaging according to customer needs.
Shipping Methods
Main Method: International Air Freight

We primarily use DHL, FedEx, UPS, and TNT because of their global reliability, speed, and advanced tracking systems. Air freight ensures the fastest transit time and minimizes the impact of environmental factors on the product.