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Glucagon (1 – 37), porcine; Oxyntomodulin, porcine CAS NO.62340-29-8

Glucagon (1-37), porcine; Oxyntomodulin, porcine is a dual-product offering featuring two distinct porcine-derived peptides: full-length glucagon (37 amino acids) and oxyntomodulin. Both peptides are derived from the same precursor (proglucagon) but exhibit different biological activities and receptor specificities. Glucagon (1-37) functions primarily as a hyperglycemic hormone targeting glucagon receptors, while oxyntomodulin acts on both glucagon-like peptide-1 (GLP-1) and glucagon receptors, influencing glucose metabolism and appetite regulation. Supplied as high-purity lyophilized powders with HPLC-verified quality and comprehensive analytical documentation, these peptides provide researchers with valuable tools for comparative metabolic studies, receptor pharmacology, and gastrointestinal hormone research in porcine models.

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TECHNICAL SPECIFICATIONS

Item	Specification
Product Name	Glucagon (1 - 37), porcine; Oxyntomodulin, porcine
CAS NO.	62340-29-8
Appearance	White to off-white lyophilized powder
Molecular Formula	C192H295N59O60S
Molecular Weight	4421.92g/mol
Purity (RP-HPLC)	≥ 95.0%
Solubility	Soluble in water, dilute acetic acid, and alkaline buffers (pH 8-10); gentle solubilization may be necessary.
Endotoxin	< 1.0 EU/mg
Biological Activity	Glucagon (1-37), porcine: Glucagon promotes glycogenolysis in the liver and raises blood glucose levels. Oxyntomodulin, porcine: A hormone secreted by L cells in the intestine, possessing multiple metabolic regulatory functions, including inhibiting gastric acid secretion, reducing food intake, and stimulating insulin release.
Storage Conditions	Store at -20°C or below, protected from light and moisture. After reconstitution, aliquot and store at -20°C
Stock Location	Stock in USA
MOQ	1g

1.MECHANISM OF ACTION

Glucagon (1-37), porcine binds to glucagon receptors (GCGR) in the liver, activating G-protein coupled signaling that increases intracellular cAMP levels. This leads to activation of protein kinase A (PKA), resulting in glycogenolysis, gluconeogenesis, and increased hepatic glucose output, ultimately raising blood glucose levels.

Oxyntomodulin, porcine exhibits dual receptor activity: it binds to both GLP-1 receptors (GLP-1R) and glucagon receptors (GCGR) with varying affinities. Activation of GLP-1R enhances insulin secretion, inhibits glucagon release, and delays gastric emptying, while interaction with GCGR may contribute to its metabolic effects. The combined receptor activation results in reduced food intake, increased energy expenditure, and improved glucose homeostasis.

2.PRODUCT INDICATIONS

Comparative Metabolic Studies: Investigation of differential effects between glucagon and oxyntomodulin on glucose metabolism and energy balance

Receptor Pharmacology: Evaluation of binding affinities and signaling pathways for GCGR and GLP-1R using porcine-specific peptides

Gastrointestinal Hormone Research: Study of proglucagon-derived peptides in appetite regulation and gut hormone interactions

Diabetes and Obesity Research: Exploration of therapeutic potential in metabolic disorders using porcine models

Species-Specific Studies: Research requiring porcine-derived peptides for physiological relevance in pig models

Preclinical Development: Assessment of metabolic effects and safety profiles in porcine systems

3.CLINICAL EFFICACY OF PRODUCT

High Purity: Both peptides ≥95% by RP-HPLC with mass spectrometry confirmation of sequence and molecular weight

Species Specificity: Porcine-derived sequences optimized for porcine receptor studies and cross-species comparison

Biological Activity Validation: Demonstrated receptor binding and functional activity in validated assay systems

Research Reproducibility: Consistent performance in metabolic assays, receptor binding studies, and animal models

Quality Documentation: Certificate of Analysis provided for each peptide with purity, mass spec, and analytical data

Technical Support: Access to species-specific application guidance and experimental design consultation

4.DELIVERY & SHIPPING

We specialize in global logistics for various cosmetic peptides. Your order will be handled with the utmost care, ensuring safe, reliable, and intact delivery.
Professional and Secure Packaging
Each bottle of peptide is protected with a special packaging solution to ensure stability and integrity during transportation.
We can also customize packaging according to customer needs.
Shipping Methods
Main Method: International Air Freight

We primarily use DHL, FedEx, UPS, and TNT because of their global reliability, speed, and advanced tracking systems. Air freight ensures the fastest transit time and minimizes the impact of environmental factors on the product.