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[Ser8]-GLP-1 (7-36) amide (human, bovine, guinea pig, mouse, rat) CAS NO.215777-46-1

[Ser8]-GLP-1 (7-36) amide (human, bovine, guinea pig, mouse, rat) is a multi-species collection of synthetic GLP-1 analogs featuring a specific serine substitution at position 8. This 30-amino acid peptide (C-terminal amide form) is available across five mammalian species, providing researchers with species-matched tools for studying GLP-1 receptor pharmacology, structure-activity relationships, and metabolic regulation. The Ser8 modification may influence peptide stability, receptor binding kinetics, and resistance to enzymatic degradation compared to native sequences. Manufactured under stringent quality controls with HPLC-verified purity and comprehensive analytical documentation, this product enables comparative studies across species and investigation of GLP-1 analog properties.

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TECHNICAL SPECIFICATIONS

Item	Specification
Product Name	[Ser8]-GLP-1 (7-36) amide (human, bovine, guinea pig, mouse, rat)
CAS NO.	215777-46-1
Appearance	White to off-white lyophilized powder
Molecular Formula	C149H226N40O46
Molecular Weight	3313.7 g/mol
Purity (RP-HPLC)	≥ 95.0%
Solubility	Soluble in water, acetic acid (0.1%), PBS (pH 7-8)
Endotoxin	< 1.0 EU/mg
Biological Activity	Glucagon-like peptide-1 analogues, with a serine (Ser) substitution at position 8; GLP-1 receptor agonists that promote insulin secretion, inhibit glucagon release, and delay gastric emptying.
Storage Conditions	Store at -20°C or below, protected from light and moisture. After reconstitution, aliquot and store at -20°C
Stock Location	Stock in USA
MOQ	1g

1.MECHANISM OF ACTION

[Ser8]-GLP-1 (7-36) amide binds to GLP-1 receptors (GLP-1R) expressed on pancreatic beta cells and other target tissues, activating G-protein coupled signaling pathways. The Ser8 substitution at position 8 (typically alanine or serine in native sequences across species) may modulate receptor interaction, potentially affecting binding affinity, signal transduction efficiency, or metabolic stability. This modification can influence the peptide's resistance to dipeptidyl peptidase-4 (DPP-4) cleavage and other proteases, potentially extending its half-life. The peptide increases intracellular cAMP levels, activates protein kinase A (PKA), and stimulates glucose-dependent insulin secretion while inhibiting glucagon release. The species-specific variants allow investigation of how single amino acid changes affect receptor activation and downstream metabolic effects.

2.PRODUCT INDICATIONS

Structure-Activity Relationship Studies: Investigation of how position 8 modifications affect GLP-1 receptor binding and signaling

Comparative Species Research: Evaluation of species-specific differences in GLP-1 receptor pharmacology and metabolic responses

Metabolic Stability Studies: Assessment of Ser8 substitution effects on peptide half-life and protease resistance

Receptor Pharmacology: Characterization of binding kinetics, affinity, and signal transduction using species-matched ligands

Diabetes Research: Exploration of modified GLP-1 analogs for therapeutic development

Cross-Species Validation: Comparison of peptide activity across human and common laboratory animal species

3.CLINICAL EFFICACY OF PRODUCT

Species Coverage: Available for human, bovine, guinea pig, mouse, and rat, enabling comprehensive cross-species research

High Purity: ≥95% by RP-HPLC with mass spectrometry confirmation of species-specific sequences and Ser8 modification

Sequence Accuracy: Each species variant verified for correct amino acid sequence, including Ser8 substitution and C-terminal amidation

Research Utility: Validated for receptor binding studies, functional assays, and species comparison experiments

Quality Documentation: Certificate of Analysis provided for each batch with purity, mass spec, and species identification

Technical Support: Access to species-specific application guidance and experimental design consultation

4.DELIVERY & SHIPPING

We specialize in global logistics for various cosmetic peptides. Your order will be handled with the utmost care, ensuring safe, reliable, and intact delivery.
Professional and Secure Packaging
Each bottle of peptide is protected with a special packaging solution to ensure stability and integrity during transportation.
We can also customize packaging according to customer needs.
Shipping Methods
Main Method: International Air Freight

We primarily use DHL, FedEx, UPS, and TNT because of their global reliability, speed, and advanced tracking systems. Air freight ensures the fastest transit time and minimizes the impact of environmental factors on the product.