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GM-CSF CAS NO.313219-94-2

GM-CSF (Granulocyte-Macrophage Colony-Stimulating Factor) is a high-purity recombinant cytokine that plays a critical role in hematopoiesis and immune regulation. This glycoprotein stimulates the proliferation, differentiation, and activation of granulocytes, macrophages, and other myeloid lineage cells. Available as lyophilized powder with HPLC-verified purity and comprehensive analytical documentation, this product is manufactured under stringent quality controls to ensure consistent biological activity. With validated performance in cell proliferation assays and functional studies, GM-CSF serves as an essential tool for immunology research, hematopoietic studies, and cancer immunotherapy development.

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TECHNICAL SPECIFICATIONS

Item	Specification
Product Name	GM-CSF (Granulocyte-Macrophage Colony-Stimulating Factor)
CAS NO.	313219-94-2
Appearance	White to off-white lyophilized powder
Molecular Formula	C73H129N27O24
Molecular Weight	1769.01g/mol
Purity (RP-HPLC)	≥ 95.0%
Solubility	Soluble in water, PBS (pH 7-7.5), or 0.1% acetic acid; brief centrifugation is recommended before dissolving to avoid vigorous vortexing and aggregation.
Endotoxin	< 1.0 EU/mg
Biological Activity	Hematopoietic growth factors; stimulate the proliferation, differentiation, and activation of myeloid cells such as granulocytes and macrophages; enhance the phagocytic, antigen-presenting, and cytokine secretion functions of leukocytes.
Storage Conditions	The freeze-dried powder should be stored at -20°C or -80°C for extended periods, avoiding repeated freeze-thaw cycles. After rehydration, it can be aliquoted and stored at -80°C for several months. For short-term use, it can be stored at 2-8°C.
Stock Location	Stock in USA
MOQ	1g

1.MECHANISM OF ACTION

GM-CSF binds to its specific heterodimeric receptor (GM-CSFR) expressed on target cells, initiating JAK/STAT signaling pathways. This binding activates downstream signaling cascades including STAT5 phosphorylation, leading to transcriptional regulation of genes involved in cell survival, proliferation, and differentiation. The cytokine promotes the expansion and maturation of myeloid progenitor cells into granulocytes, macrophages, and dendritic cells. Additionally, GM-CSF enhances the functional activity of mature immune cells, including phagocytosis, antigen presentation, and cytokine production. The signaling cascade also involves MAPK and PI3K pathways, contributing to the pleiotropic effects on immune cell activation and survival.

2.PRODUCT INDICATIONS

Hematopoietic Research: Study of myeloid cell differentiation, proliferation, and colony formation in vitro

Immunology Studies: Investigation of immune cell activation, cytokine production, and antigen presentation

Cancer Immunotherapy: Evaluation of GM-CSF as an immune adjuvant in vaccine development and adoptive cell therapy

Inflammation Research: Exploration of GM-CSF roles in inflammatory responses and autoimmune diseases

Cell Culture Applications: Expansion and maintenance of myeloid-derived cells, dendritic cells, and macrophages

Preclinical Development: Assessment of GM-CSF effects in animal models of hematopoiesis and immune disorders

3.CLINICAL EFFICACY OF PRODUCT

Biological Activity: Validated in cell proliferation assays (e.g., TF-1 cells) with specific activity ≥ 1 × 10⁷ IU/mg

Endotoxin Level: < 1.0 EU/µg (suitable for cell culture and in vitro studies)

Sequence Verification: Confirmed by mass spectrometry and amino acid analysis

Research Reproducibility: Consistent performance across multiple batches and experimental systems

Quality Documentation: Certificate of Analysis provided with purity, activity, and analytical data

Technical Support: Access to application guidance and experimental optimization consultation

4.DELIVERY & SHIPPING

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Professional and Secure Packaging
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Shipping Methods
Main Method: International Air Freight

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