gp100 (476-485)

gp100 (476-485) is a high-purity synthetic peptide representing an HLA-A*0201-restricted cytotoxic T lymphocyte (CTL) epitope derived from the human melanoma-associated antigen gp100/pMel 17. This 10-amino acid peptide (ILTPPSSLRL) serves as an immunogenic epitope that can be presented by MHC class I molecules to activate antigen-specific CD8+ T cells. Manufactured under stringent quality controls with HPLC-verified purity and comprehensive analytical documentation, this product provides researchers with a reliable tool for studying T cell responses, developing cancer vaccines, and evaluating immunotherapeutic strategies, particularly in melanoma research. It complements other gp100 epitopes (such as 177-186) for comprehensive immune monitoring and therapy development.

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TECHNICAL SPECIFICATIONS

Item	Specification
Product Name	gp100 (476-485)
CAS NO.	/
Appearance	White to off-white lyophilized powder
Molecular Formula	C57H83N13O15
Molecular Weight	1190.38g/mol
Purity (RP-HPLC)	≥ 95.0%
Solubility	Soluble in DMSO, PBS (pH 7-8), or physiological saline.
Endotoxin	< 1.0 EU/mg
Biological Activity	Another HLA-A*0201-restricted CTL epitope of human melanoma-associated antigen gp100/pMel 17 (corresponding to positions 476-485); it can induce a specific CD8+ T cell immune response and is used in tumor immunology, vaccines, and T cell therapy research.
Storage Conditions	Store at -20°C or below, protected from light and moisture. After reconstitution, aliquot and store at -20°C
Stock Location	Stock in USA
MOQ	1g

1.MECHANISM OF ACTION

gp100 (476-485) functions as a tumor-associated antigen peptide that binds to HLA-A0201 molecules on antigen-presenting cells (APCs), forming peptide-MHC complexes that are recognized by T cell receptors (TCRs) on CD8+ T cells. This specific interaction triggers T cell activation, proliferation, and differentiation into cytotoxic T lymphocytes (CTLs). The activated CTLs then recognize and eliminate tumor cells expressing the gp100 antigen through perforin/granzyme-mediated cytotoxicity and cytokine release (such as IFN-γ). The peptide's immunogenicity is characterized by its ability to induce robust T cell responses in HLA-A0201-positive individuals, making it valuable for both in vitro and in vivo immunological studies.

2.PRODUCT INDICATIONS

T Cell Activation Studies: In vitro stimulation and expansion of antigen-specific CD8+ T cells targeting gp100

Cancer Vaccine Development: Assessment of gp100-based vaccine candidates in preclinical models

Immune Monitoring: ELISPOT, intracellular cytokine staining, and tetramer assays for T cell detection

TCR Screening: Identification and validation of T cell receptors specific for gp100 epitope

Comparative Epitope Studies: Evaluation of immune responses to different gp100 epitopes (e.g., 177-186 vs 476-485)

Cancer Immunotherapy Research: Evaluation of T cell responses and immune activation in melanoma and other malignancies

3.CLINICAL EFFICACY OF PRODUCT

Immunogenic Activity: Validated for T cell activation in HLA-A*0201-restricted systems

Sequence Accuracy: Verified 10-amino acid sequence (ILTPPSSLRL) corresponding to gp100 476-485

Research Reproducibility: Consistent performance in T cell stimulation and immune assays

Quality Documentation: Certificate of Analysis provided with purity, mass spec, and analytical data

Technical Support: Access to application guidance for cancer immunotherapy research

4.DELIVERY & SHIPPING

We specialize in global logistics for various cosmetic peptides. Your order will be handled with the utmost care, ensuring safe, reliable, and intact delivery.
Professional and Secure Packaging
Each bottle of peptide is protected with a special packaging solution to ensure stability and integrity during transportation.
We can also customize packaging according to customer needs.
Shipping Methods
Main Method: International Air Freight

We primarily use DHL, FedEx, UPS, and TNT because of their global reliability, speed, and advanced tracking systems. Air freight ensures the fastest transit time and minimizes the impact of environmental factors on the product.