gp100 (457-466)
TECHNICAL SPECIFICATIONS
| Item | Specification |
|---|---|
| Product Name | gp100 (457-466) |
| CAS NO. | |
| Appearance | White to off-white lyophilized powder |
| Molecular Formula | C47H85N13O15 |
| Molecular Weight | 1035.24g/mol |
| Amino Acid Sequence | H-LELDGTATL-OH (human gp100 residues 457‑466, HLA‑A*0201‑restricted epitope) |
| Purity (RP-HPLC) | ≥95.0% |
| Solubility | Soluble in DMSO, PBS, or sterile water (may require sonication) |
| Endotoxin | ≤1.0 EU/mg |
| Biological Activity | HLA‑A*0201‑restricted melanoma‑associated antigen peptide; used in cancer immunotherapy research, T‑cell activation studies, and vaccine development. |
| Storage Conditions | Store at –20°C, protected from light and moisture. For long-term storage, recommend –80°C. |
| Stock Location | Stock in USA |
| MOQ | 10mg |
1.MECHANISM OF ACTION
This peptide functions as a HLA-A*0201-restricted antigenic epitope derived from the gp100 melanoma-associated antigen. It is presented on the surface of antigen-presenting cells, leading to the activation and proliferation of cytotoxic T lymphocytes (CTLs) that specifically target and destroy gp100-expressing tumor cells, thereby initiating a targeted anti-tumor immune response.
2.PRODUCT INDICATIONS
gp100 (457-466) is primarily used in the research and development of cancer immunotherapies, including peptide-based vaccines and adoptive T-cell therapies, specifically for melanoma. It is also employed in immunological assays, T-cell activation studies, and preclinical evaluation of immune checkpoint combination strategies.
3.CLINICAL EFFICACY OF PRODUCT
Clinical studies involving gp100 (457-466) in combination with immune-modulating agents have demonstrated its potential to elicit antigen-specific T-cell responses and contribute to tumor regression in a subset of melanoma patients. Its efficacy underscores its role as a critical component in the development of next-generation immunotherapeutic strategies.
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