Guanylin, human CAS NO.183200-12-6

Guanylin, human is a high-purity synthetic 15-amino acid peptide that serves as the endogenous ligand for guanylate cyclase-C (GC-C) receptor. This gastrointestinal peptide plays a crucial role in regulating intestinal fluid secretion and electrolyte balance through the cGMP signaling pathway. Manufactured under stringent quality controls with HPLC-verified purity and comprehensive analytical documentation, this product provides researchers with a reliable tool for studying gastrointestinal physiology, secretory diarrhea mechanisms, and GC-C receptor signaling. With validated biological activity in cell-based assays and structural confirmation of disulfide bonds, Guanylin enables investigations into intestinal barrier function, fluid homeostasis, and related pathophysiological conditions.

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TECHNICAL SPECIFICATIONS

Item	Specification
Product Name	Guanylin, human
CAS NO.	183200-12-6
Appearance	White to off-white lyophilized powder
Molecular Formula	C58H87N15O21S4
Molecular Weight	1458.68g/mol
Purity (RP-HPLC)	≥ 95.0%
Solubility	Soluble in water, PBS (pH 7‑8), dilute acetic acid
Endotoxin	< 1.0 EU/mg
Biological Activity	Intestinal guanylate cyclase agonist; binds to and activates guanylate cyclase-C (GC-C), increases intracellular cGMP, and regulates intestinal fluid secretion and electrolyte balance.
Storage Conditions	Store at -20°C or below, protected from light and moisture. After reconstitution, aliquot and store at -20°C
Stock Location	Stock in USA
MOQ	1g

1.MECHANISM OF ACTION

Guanylin binds specifically to the extracellular domain of guanylate cyclase-C (GC-C) receptors expressed on intestinal epithelial cells. This binding activates the intracellular catalytic domain of GC-C, leading to the conversion of GTP to cyclic GMP (cGMP). The elevated intracellular cGMP levels activate protein kinase G (PKG) and other downstream effectors, resulting in phosphorylation of the cystic fibrosis transmembrane conductance regulator (CFTR) chloride channel. This cascade ultimately stimulates chloride and bicarbonate secretion into the intestinal lumen, while inhibiting sodium absorption. The net effect is increased fluid secretion and altered electrolyte transport, which plays a critical role in maintaining intestinal fluid homeostasis and responding to enteric pathogens.

2.PRODUCT INDICATIONS

Gastrointestinal Physiology Research: Investigation of intestinal fluid secretion and electrolyte transport mechanisms

Secretory Diarrhea Studies: Evaluation of Guanylin's role in infectious and inflammatory diarrhea models

GC-C Receptor Signaling: Characterization of guanylate cyclase-C activation and downstream pathways

Intestinal Barrier Function: Assessment of epithelial barrier integrity and paracellular permeability

Drug Discovery: Screening for GC-C agonists or antagonists for therapeutic applications

Comparative Studies: Evaluation of Guanylin activity compared to related peptides (uroguanylin, STa toxin)

3.CLINICAL EFFICACY OF PRODUCT

Structural Integrity: Verified disulfide bond formation (Cys3-Cys12, Cys6-Cys13) essential for biological activity

Biological Activity: Validated in cell-based assays measuring cGMP production or chloride secretion

Sequence Accuracy: Verified 15-amino acid sequence corresponding to human Guanylin

Research Reproducibility: Consistent performance in functional assays across multiple batches

Quality Documentation: Certificate of Analysis provided with purity, mass spec, and analytical data

Technical Support: Access to application guidance for gastrointestinal research

4.DELIVERY & SHIPPING

We specialize in global logistics for various cosmetic peptides. Your order will be handled with the utmost care, ensuring safe, reliable, and intact delivery.
Professional and Secure Packaging
Each bottle of peptide is protected with a special packaging solution to ensure stability and integrity during transportation.
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Shipping Methods
Main Method: International Air Freight

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