Calcium/Calmodulin Dependent Protein Kinase II – g (345 – 358) CAS NO.139143-29-6
TECHNICAL SPECIFICATIONS
| Item | Specification |
|---|---|
| Product Name | Calcium/Calmodulin Dependent Protein Kinase II – γ (345‑358) |
| CAS NO. | 139143-29-6 |
| Appearance | White to off-white lyophilized powder |
| Molecular Formula | C58H107N21O22 |
| Molecular Weight | 1450.63/mol |
| Amino Acid Sequence | R‑M‑P‑S‑F‑K‑R‑R‑Q‑K‑V‑K‑K‑N (single‑letter notation; corresponds to CaMKII‑γ residues 345‑358) |
| Purity (RP-HPLC) | ≥95.0% |
| Solubility | Soluble in water, PBS, or aqueous buffers; soluble in DMSO for higher‑concentration stock solutions |
| Endotoxin | ≤1.0 EU/mg |
| Biological Activity | Synthetic peptide corresponding to a functional domain of CaMKII‑γ; commonly used as a substrate or inhibitor in kinase activity assays, Ca²⁺/calmodulin‑dependent signaling studies, and neurological/cardiovascular research. |
| Storage Conditions | Store at –20°C, protected from light and moisture. For long-term storage, recommend –80°C. |
| Stock Location | Stock in USA |
| MOQ | 10mg |
1.MECHANISM OF ACTION
This peptide acts as a substrate or modulatory sequence for CaMKII‑γ, a key enzyme in calcium/calmodulin‑dependent signaling. It helps study the phosphorylation events and regulatory mechanisms involved in neuronal plasticity, cardiovascular function, and cellular response to calcium signals.
2.PRODUCT INDICATIONS
Calcium/Calmodulin Dependent Protein Kinase II – γ (345‑358) is applied in kinase activity assays, signal transduction research, and studies of calcium‑mediated cellular processes in neuroscience, cardiology, and cell biology.
3.CLINICAL EFFICACY OF PRODUCT
This product is intended for research use only and is not designed for direct clinical application. Its value lies in enabling the investigation of CaMKII‑related pathways that underlie various physiological and pathological conditions, supporting the development of future therapeutic strategies.
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