Protein Kinase C (530-558)

Protein Kinase C (530-558) is a high-purity synthetic peptide representing a specific functional domain fragment of PKC, typically corresponding to residues 530-558 of a specific PKC isoform (such as PKCα, PKCδ, or other isoforms). This 29-amino acid peptide is designed to target key regulatory or catalytic regions of PKC, enabling researchers to study kinase activation, protein-protein interactions, and signal transduction mechanisms. Manufactured under stringent quality controls with HPLC-verified purity and comprehensive analytical documentation, this product provides a specialized tool for investigating PKC-dependent signaling pathways, substrate recognition, and cellular localization. The peptide's specific sequence varies by PKC isoform, allowing for isoform-specific research applications in various biological contexts.

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TECHNICAL SPECIFICATIONS

Item	Specification
Product Name	Protein Kinase C (530-558)
CAS NO.	/
Appearance	White to off-white lyophilized powder
Molecular Formula	C148H220N34O51S2
Molecular Weight	3354.7g/mol
Purity (RP-HPLC)	≥ 95.0%
Solubility	Soluble in water, PBS (pH 7-8), and dilute acetic acid; gentle sonication may be necessary to aid dissolution.
Endotoxin	< 1.0 EU/mg
Biological Activity	Functional domain fragments of PKC; potentially involved in binding to regulatory molecules, substrates, or self-inhibition, used to study PKC activation, localization, signal transduction, and protein-protein interactions.
Storage Conditions	Store at -20°C or below, protected from light and moisture. After reconstitution, aliquot and store at -20°C
Stock Location	Stock in USA
MOQ	1g

1.MECHANISM OF ACTION

Protein Kinase C (530-558) functions by mimicking specific structural domains of the full-length PKC enzyme. Depending on the isoform and exact sequence, this peptide may act through several mechanisms: (1) As a pseudosubstrate inhibitor that binds to the catalytic site of PKC, competitively blocking substrate access and inhibiting kinase activity; (2) As a regulatory domain fragment that interacts with anchoring proteins or scaffold molecules, modulating PKC subcellular localization and activation; or (3) As a protein interaction motif that binds to specific substrates, co-regulators, or membrane components, thereby influencing signal complex assembly. The peptide's activity is sequence-dependent and isoform-specific, allowing targeted manipulation of PKC signaling without affecting other kinases.

2.PRODUCT INDICATIONS

Protein-Protein Interaction Research: Investigation of PKC binding partners and signal complex formation

Subcellular Localization: Evaluation of PKC membrane translocation and compartmentalization

Isoform-Specific Research: Comparative studies of different PKC isoforms and their distinct functions

Signal Transduction Pathways: Analysis of PKC-dependent signaling in cell proliferation, differentiation, and apoptosis

Drug Discovery: Screening for PKC modulators and validation of inhibitor specificity

3.CLINICAL EFFICACY OF PRODUCT

Sequence Accuracy: Verified amino acid sequence corresponding to the specified PKC isoform (530-558)

Biological Activity: Validated in functional assays (e.g., kinase inhibition, binding assays) as appropriate for the specific sequence

Research Reproducibility: Consistent performance across multiple batches and experimental conditions

Quality Documentation: Certificate of Analysis provided with purity, mass spec, and analytical data

Technical Support: Access to application guidance for PKC research and isoform-specific protocols

4.DELIVERY & SHIPPING

We specialize in global logistics for various cosmetic peptides. Your order will be handled with the utmost care, ensuring safe, reliable, and intact delivery.
Professional and Secure Packaging
Each bottle of peptide is protected with a special packaging solution to ensure stability and integrity during transportation.
We can also customize packaging according to customer needs.
Shipping Methods
Main Method: International Air Freight

We primarily use DHL, FedEx, UPS, and TNT because of their global reliability, speed, and advanced tracking systems. Air freight ensures the fastest transit time and minimizes the impact of environmental factors on the product.